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CSN2 Antikörper

CSN2 Reaktivität: Maus, Ratte IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7073324
  • Target Alle CSN2 Antikörper anzeigen
    CSN2 (Casein beta (CSN2))
    Reaktivität
    • 48
    • 47
    • 34
    • 2
    • 1
    Maus, Ratte
    Wirt
    • 73
    • 3
    Kaninchen
    Klonalität
    • 74
    • 2
    Polyklonal
    Konjugat
    • 20
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    Dieser CSN2 Antikörper ist unkonjugiert
    Applikation
    • 69
    • 28
    • 27
    • 27
    • 11
    • 7
    • 6
    • 4
    • 4
    • 2
    • 1
    Immunohistochemistry (IHC), Immunofluorescence (IF)
    Kreuzreaktivität
    Ratte
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant protein corresponding to Mouse CSN2
    Top Product
    Discover our top product CSN2 Primärantikörper
  • Applikationshinweise
    IHC/IF (M,R) 1:700-1:1400
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS, pH 7.4, 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Target
    CSN2 (Casein beta (CSN2))
    Andere Bezeichnung
    CSN2 (CSN2 Produkte)
    Synonyme
    CASB antikoerper, Csnb antikoerper, casein beta antikoerper, CSN2 antikoerper, Csn2 antikoerper
    Hintergrund
    COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
    Gen-ID
    12848
    NCBI Accession
    NP_001272441
    UniProt
    P61202
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