BPTF Antikörper

Produktnummer ABIN7073234

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BPTF in IHC und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für BPTF Antikörper (ABIN7073234)

Target: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BPTF Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-BPTF Antikörper

Kreuzreaktivität: Maus, Ratte

Aufreinigung: Affinity purification

Immunogen: Recombinant protein corresponding to Human BPTF

Anwendungsinformationen

Applikationshinweise: IHC/IF (H,M,R) 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu BPTF

Target: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Andere Bezeichnung: BPTF/FALZ

Hintergrund: FALZ/BPTF is a histone-binding component of NURF (nucleosome remodeling factor), a complex that catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. This gene was identified in brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), containing a DNA-binding domain, a zinc finger motif, and a C-terminal bromodomain, suggested it might play a role in the regulation of transcription during proliferation. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. This protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription.

Gen-ID: 2186

NCBI Accession: NP_004450

UniProt: Q12830