Der Kaninchen Polyklonal Anti-ANP32B Antikörper wurde für WB, IHC und IF validiert. Er ist geeignet, ANP32B in Proben von Human, Maus und Ratte zu detektieren.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Target
ANP32B
(Acidic (Leucine-Rich) Nuclear phosphoprotein 32 Family, Member B (ANP32B))
Andere Bezeichnung
PHAPI2 / APRIL
Hintergrund
ANP32B is a member of the highly conserved acidic leucine-rich nuclear phosphoprotein 32 (ANP32) family. The ANP32 proteins have been implicated in a broad array of physiological processes, including cell differentiation, apoptotic cell death, and cell proliferation. ANP32B was identified as a novel direct substrate for caspase-3 and acted as a negative regulator for leukemic cell apoptosis. ANP32B controls the expression of the dendritic cell maturation factor CD83 by regulating the transport of its mRNA to the cytoplasm. It also modulates the activity of the transcription factor Kruppel-like factor 5 (KLF5).