Rekombinanter Mesothelin Antikörper

Produktnummer ABIN7072729

Dieser Maus Monoklonal Antikörper detektiert spezifisch Mesothelin in ELISA, FACS und IP. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter Mesothelin Antikörper (ABIN7072729)

Target: Mesothelin (MSLN)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Mesothelin Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP)

Klon: 11-25

Produktdetails anti-Mesothelin Antikörper

Verwendungszweck: Anti-Mesothelin [11-25], Mouse IgG2b, kappa

Spezifität: This antibody binds the human mesothelin protein which is highly expressed in many human cancers, including the majority of pancreatic adenocarcinomas, ovarian cancers, and mesotheliomas.

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG2b

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was generated by intraperitoneally immunizing BALB/c mice with the purified recombinant mesothelin protein.

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: This antibody is recommended to be used in combination with mAb IC14-30 for detecting mesothelin with high sensitivity in a capture ELISA. This antibody can also immunoprecipitate recombinant mesothelin. NCI-H226 and NCI-H520 were incubated with anti-MSLN antibodies (11-25 ) or an isotype-matched control antibody and followed by PE-conjugate anti mouse IgG. Antigen expression was detected by flow cytometry (PMID: 18394747). 64Cu labelled 11-25 was used in vitro cell binding assay and in vivo positron emission tomography (PET) imaging in the tumor-bearing mice (PMID: 25883990).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu Mesothelin

Target: Mesothelin (MSLN)

Andere Bezeichnung: Mesothelin

Hintergrund: MSLN, CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor

UniProt: Q13421

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process