Rekombinanter SARS-CoV-2 Spike Antikörper (C-Term, Extracellular Domain, RBD)

Produktnummer ABIN7072713

Der Human Chimeric anti-SARS-CoV-2 Spike Antikörper (Klon Sb#14) (ABIN7072713) detektiert spezifisch SARS-CoV-2 Spike in ELISA, Inh und GCI. Dieser Antikörper reagiert spezifisch mit Proben aus SARS Coronavirus-2 (SARS-CoV-2).

Kurzübersicht für Rekombinanter SARS-CoV-2 Spike Antikörper (C-Term, Extracellular Domain, RBD) (ABIN7072713)

Target: SARS-CoV-2 Spike (SARS-CoV-2 S)

Antikörpertyp: Recombinant Antibody

Reaktivität: SARS Coronavirus-2 (SARS-CoV-2)

Wirt: Human

Klonalität: Chimeric

Konjugat: Dieser SARS-CoV-2 Spike Antikörper ist unkonjugiert

Applikation: ELISA, Inhibition (Inh), Grating Coupled Interferometry (GCI)

Klon: Sb#14

Produktdetails anti-SARS-CoV-2 Spike Antikörper

Bindungsspezifität: C-Term, Extracellular Domain, RBD

Verwendungszweck: Anti-Spike protein (RBD) [Sb#14], Human IgG1-Fc Fusion, Fc Silent™,

Spezifität:

This antibody recognizes and binds the SARS CoV 2 C-terminal receptor binding domain (RBD) located in the extracellular portion of the spike protein.

Application Notes original Clone: This antibody is recommended for detection of SARS CoV 2 or 2019-nCoV. Its high specificity to the novel coronavirus SARS-Cov-2 was confirmed via ELISA testing (Walter et al., 2020). Furthermore, grating-coupled interferometry demonstrated that this antibody binds the receptor binding domain (RBD) of the spike protein with high affinity (Walter et al., 2020). Subsequent testing showed that this clone exhibits exceptionally strong inhibition of binding of SARS-Cov-2 RBD to hACE2, which is the receptor for the virus (signal of RBD association with hACE2 decreased over 90 % ) (Walter et al., 2020).

Produktmerkmale: This chimeric human antibody was made using the variable domain sequences of the original VHH format, for improved compatibility with existing reagents, assays and techniques.

Aufreinigung: Purified antibody.

Immunogen: This clone was originally isolated in a form of a synthetic nanobody (sybody) via a 'target swap' selection procedure against RBD-vYFP using ribosomal display and against RBD-Fc fusion during phage display rounds.

Isotyp: Fc Silenced, IgG1-Fc Fusion

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

OriginalSpeciesName: Dromedary

OriginalFormat: VHH

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu SARS-CoV-2 Spike

Target: SARS-CoV-2 Spike (SARS-CoV-2 S)

Andere Bezeichnung: SARS-CoV2 Spike protein

Substanzklasse: Viral Protein

Hintergrund: Receptor Binding Domain, SARS CoV 2 S glycoprotein, Sb45, COVID-19 Spike protein, RBD, Receptor Binding Domain, E2 glycoprotein, E2, Human coronavirus 2 spike glycoprotein, Peplomer protein, S glycoprotein, SARS coronavirus 2 S protein, SARS coronavirus 2 Spike Protein, SARS CoV 2 Spike protein, SARS CoV 2, SARS-CoV-2 S protein, SARSCoV2, SARS-COV-2 S protein, SARS-COV-2 Spike glycoprotein, SARSCOV2 Spike protein, Severe acute respiratory syndrome 2 spike glycoprotein, Severe acute respiratory syndrome virus 2 spike glycoprotein, Spike glycoprotein, 2019-nCoV, SARS-CoV2

UniProt: P0DTC2