Rekombinanter CCR7 Antikörper

Produktnummer ABIN7072672

Dieses Kaninchen Chimeric-Antikörper erkennt spezifisch CCR7 in FACS, IP und Func. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für Rekombinanter CCR7 Antikörper (ABIN7072672)

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Antikörpertyp: Recombinant Antibody

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser CCR7 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)

Klon: 4B12

Produktdetails anti-CCR7 Antikörper

Verwendungszweck: Anti-CCR7 [4B12], Rabbit IgG, kappa

Spezifität: This antibody is specific to the mouse CCR7 protein, which was confirmed by immunoprecipitation (Ritter et al, 2004).

Produktmerkmale:

Original Species of Ab: Rat

Original Format of Ab: IgG2a

Aufreinigung: Protein A affinity purified

Immunogen: This antibody was raised by immunizing rats with mouse CCR7 antigen.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: This antibody was used for flow cytometry and the staining quality can be improved by incubation at 37 °C (Britschgi et al, 2008). This antibody is widely used to monitor the activation of dendritic cells in mice (Ohl et al, 2004, Ritter et al, 2004, Zhao et al, 2019). It was also utilized in immunoprecipitation of the CCR7 receptor protein (Ritter et al, 2004). The antibody does not interfere with ligands binding to the CCR7 receptor, which was confirmed by a transmigration assay (Ritter et al, 2004). It does not interfere with T-cell migration (Ritter et al, 2004). The antibody also is not agonistic as it does not activate the receptor (Ritter et al, 2004).

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu CCR7

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Andere Bezeichnung: CCR7

Hintergrund: EBI1, EBV-induced G-protein coupled receptor 1, Epstein-Barr virus-induced G-protein coupled receptor 1, MIP-3 beta receptor, CD197, C-C CKR-7, CC-CKR-7, C-C chemokine receptor type 7

UniProt: P47774

Pathways: Regulation of Actin Filament Polymerization, Positive Regulation of Immune Effector Process