Rekombinanter EGFR (Nimotuzumab Biosimilar) Antikörper
Kurzübersicht für Rekombinanter EGFR (Nimotuzumab Biosimilar) Antikörper (ABIN7072381)
Target
Antikörpertyp
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Verwendungszweck
- Anti-EGFR domain III [h-R3 (Nimotuzumab)], Human IgG1, kappa
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Spezifität
- Binds to human EGFR domain III at a site distinct from antibody 7A7 (Ab00134) (Talavera et al. 2011)
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Produktmerkmale
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Original Species of Ab: Human
Original Format of Ab: IgG1
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Aufreinigung
- Protein A affinity purified
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Immunogen
- This antibody we generated by humanisation of the murine antibody R3, raised against EGFR purified from placenta membranes and A431 tumors.
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Isotyp
- IgG1 kappa
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Applikationshinweise
- This antibody binds to human EGFR and inhibits EGF-dependent clonogenic growth of NRK cells and completely blocks EGF stimulated autophosphorylation of the receptor (Fernandez 1992)
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % Proclin 300.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- EGFR (Nimotuzumab Biosimilar)
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Substanzklasse
- Biosimilar
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Hintergrund
- ERBB-D3, ERBB1, HER1, PIG61, mENA, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, proto-oncogene c-ErbB-1, receptor tyrosine-protein kinase erbB-1, epidermal growth factor
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UniProt
- P00533
Target
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