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Rekombinanter Integrin beta 7 Antikörper

Der Rabbit Chimeric Anti-Integrin beta 7-Antikörper wurde für FACS, IP, BR validiert. Er ist geeignet, Integrin beta 7 in Proben von Human, Mouse zu detektieren.
Produktnummer ABIN7072355

Kurzübersicht für Rekombinanter Integrin beta 7 Antikörper (ABIN7072355)

Target

Alle Integrin beta 7 (ITGB7) Antikörper anzeigen
Integrin beta 7 (ITGB7)

Antikörpertyp

Recombinant Antibody

Reaktivität

  • 77
  • 30
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 50
  • 20
  • 7
  • 4
  • 1
Kaninchen

Klonalität

  • 52
  • 29
  • 1
Chimeric

Konjugat

  • 36
  • 8
  • 5
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Integrin beta 7 Antikörper ist unkonjugiert

Applikation

  • 41
  • 27
  • 22
  • 13
  • 13
  • 9
  • 8
  • 7
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Reagent (BR)

Klon

FIB27
  • Verwendungszweck

    Anti-Integrin beta-7 [FIB27], Rabbit IgG, kappa

    Spezifität

    FIB27 binds specifically to both human and mouse integrin beta-7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta-7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.

    Kreuzreaktivität

    Maus

    Produktmerkmale

    Original Species of Ab: Rat

    Original Format of Ab: IgG2a

    Aufreinigung

    Protein A affinity purified

    Immunogen

    FIB27 was prepared by immunizing rats with TK1 cells.

    Isotyp

    IgG kappa
  • Applikationshinweise

    FIB27 can be used for FC, IP and can block TKI cell aggregation and beta-7 intergrin-mediated cell adhesion.

    Kommentare

    This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    PBS with 0.02 % Proclin 300.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target

    Integrin beta 7 (ITGB7)

    Andere Bezeichnung

    Integrin beta-7

    Hintergrund

    FIB-27, FIB 27, Fib-27, Fib27, Fib 27, fib27, fib-27, fib 27, Integrin b7, integrin b-7, ITGB7, Gut homing receptor beta subunit

    Pathways

    Integrin Complex
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