Rekombinanter GPIIb/IIIa Antikörper

Produktnummer ABIN7072340

Der Kaninchen Chimeric Anti-GPIIb/IIIa-Antikörper wurde für ELISA, IF und WB validiert. Er ist geeignet, GPIIb/IIIa in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter GPIIb/IIIa Antikörper (ABIN7072340)

Target: GPIIb/IIIa (Platelet Glycoprotein IIb-IIIa Complex (GPIIb/IIIa))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser GPIIb/IIIa Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF), Western Blotting (WB)

Klon: 10E5

Produktdetails anti-GPIIb/IIIa Antikörper

Verwendungszweck: Anti-GPIIb/IIIa [10E5], Rabbit IgG, kappa

Spezifität: The antibody binds to GPIIb/IIIa with an affinity (Kd) of 16.2±6 nM. The antibody completely inhibits platelet aggregation at 7.8 μg/mL.

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG2a

Aufreinigung: Protein A affinity purified

Immunogen: Human blood platelets.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: The antibody binds specifically to human GPIIb/IIIa, and integrin complex of membrane glycoproteins expressed on the surface of platelets. The GPIIb/IIIa complex acts as a receptor for fibrinogen and Von Willebran factor, hemostatic glycoproteins that mediate platelet aggregation and blood coagulation. The monoclonal antibody 10E5 inhibits the binding of fibrinogen to its platelet receptor, preventing the platelet aggregation, to be used during coronary artery surgeries such as angioplasty. The antibody is also useful in the study of the disease Glanzmann's thrombasthenia, caused by defects in GPIIb/IIIa, and of immune thrombocytopenic purpura, where autoantibodies are produced against GPIIb/IIIa.

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu GPIIb/IIIa

Target: GPIIb/IIIa (Platelet Glycoprotein IIb-IIIa Complex (GPIIb/IIIa))

Andere Bezeichnung: GPIIb/IIIa

Hintergrund: Integrin alpha-IIb/beta-3, Glycoprotein IIb/IIIa, αIIbβ3

UniProt: P08514