Rekombinanter FOLR2 Antikörper

Produktnummer ABIN7072338

Dieses Anti-FOLR2-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von FOLR2 in WB und IHC. Geeignet für Maus.

Kurzübersicht für Rekombinanter FOLR2 Antikörper (ABIN7072338)

Target: FOLR2 (Folate Receptor 2 (Fetal) (FOLR2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser FOLR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: CL10

Produktdetails anti-FOLR2 Antikörper

Verwendungszweck: Anti-Folate receptor beta [CL10], Rat IgG2a, kappa

Produktmerkmale:

Original Species of Ab: Rat

Original Format of Ab: IgG2a

Aufreinigung: Protein A affinity purified

Immunogen: FRbeta -transfected RBL2H3 cells.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: The antibody binds specifically to FRβ, a member of the folate receptor family. The receptor binds with high affinity to folic acid and folic acid derivatives, and transports 5-methyltetrahydrofolate into the cell. The receptor is expressed on the surface of tumour associated macrophages (TAMs) that promote growth and metastasis of tumours such as gliomas and colon, breast and lung carcinomas. Research has shown FRβ is only expressed on activated macrophages, and thereby a monoclonal antibody that targets the receptor can be useful in the diagnosis of the cancer. Furthermore, the antibody may be conjugated with a toxin, delivering the drug only to TAMs and not to healthy macrophages.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu FOLR2

Target: FOLR2 (Folate Receptor 2 (Fetal) (FOLR2))

Andere Bezeichnung: Folate receptor beta

Hintergrund: FRβ, Folate receptor 2, Folate-binding protein 2.

UniProt: Q05685

Pathways: Dicarboxylic Acid Transport