Rekombinanter LeY Antikörper

Produktnummer ABIN7072332

Der Maus Monoklonal anti-LeY Antikörper (Klon BR96) (ABIN7072332) detektiert spezifisch LeY in ELISA und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter LeY Antikörper (ABIN7072332)

Target: LeY

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Klon: BR96

Produktdetails

Verwendungszweck: Anti-LeY [BR96], Mouse IgG1, kappa

Spezifität: The antibody binds Le(Y) with a Ka of 0.1 μM.

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG3

Aufreinigung: Protein A affinity purified

Immunogen: H3396 cultured line established from a metastasis of a human breast adenocarcinoma.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: The antibody binds specifically to LeY tetrasaccharide, a carbohydrate antigen expressed at the cell surface of selective carcinomas, including those of the colon, breast, ovary and lung. Studies have shown that the monoclonal antibody has toxic effects to antigen-positive tumour cells, performing ADCC at concentrations down to 0.1 μg/mL. The antibody B396 was also shown to perform complement-dependent cytotoxicity at concentrations of 0.1-5.0 μg/mL in certain carcinoma cell lines. The monoclonal antibody also has the ability to be internalised by antigen-positive tumour cells, and can thereby be used to deliver anti-cancer drugs to the specific tumour cells.

Kommentare:

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG3 format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Antigendetails

Target: LeY

Hintergrund: Lewis Y