Rekombinanter CD28 Antikörper

Produktnummer ABIN7072327

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD28 in FACS, ELISA, Func, Act, BP und in vivo. Er zeigt eine Reaktivität gegenüber Hund.

Kurzübersicht für Rekombinanter CD28 Antikörper (ABIN7072327)

Target: CD28

Antikörpertyp: Recombinant Antibody

Reaktivität: Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD28 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA, Functional Studies (Func), Activation (Act), Blocking Peptide (BP), In vivo Studies (in vivo)

Klon: 1C6

Produktdetails anti-CD28 Antikörper

Verwendungszweck: Anti-CD28 [1C6], Mouse IgG1, kappa

Spezifität: The antibody binds specifically to canine CD28, a self-surface receptor expressed by thymocytes and a subset of natural killer cells. CD28 acts as a receptor for CD80 and CD86, providing a costimulatory signal for the activation of T-cells and the production of interleukins, such as IL-6.

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: Canine CD28.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: This antibody exhibits an antagonistic activity, blocking mixed lymphocyte reactions and cytotoxic T lymphocyte-mediated killing. The use of this antibody to neutralize the CD26 signal following T-cell receptor activation is of clinical importance for transplantation therapy, as it has been shown to prevent graft rejection and graft-versus-host disease in the canine model of allogeneic hematopoietic cell transplantation (HCT). Interestingly, this antibody also exhibits agnostic activity, it was coated onto magnetic beads and used for the activation of canine peripheral blood lymphocytes (Szopa et al., 2021, PMID: 33679741).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu CD28

Target: CD28

Andere Bezeichnung: CD28

Hintergrund: TP44, Costimulatory molecule B7 receptor CD28, T-cell costimulatory molecule CD28

UniProt: Q9N0N8

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response