Rekombinanter CD28 Antikörper

Produktnummer ABIN7072235

Der Kaninchen Chimeric Anti-CD28-Antikörper wurde für FACS, IF, IHC, CoSt und Agon validiert. Er ist geeignet, CD28 in Proben von Ratte zu detektieren.

Kurzübersicht für Rekombinanter CD28 Antikörper (ABIN7072235)

Target: CD28

Antikörpertyp: Recombinant Antibody

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser CD28 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Co-Stimulation (CoSt), Agonist (Agon)

Klon: JJ316

Produktdetails anti-CD28 Antikörper

Verwendungszweck: Anti-CD28 [JJ316], Rabbit IgG, kappa

Spezifität: Recognises rat CD28 and can trigger T-cell proliferation in vitro and in vivo.

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: Made by immunizing BALB/c mice with rat CD28 cDNA-transfected A20/J cells.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: This antibody binds rat CD28 and can convey as a co-stimulatory signal. At 100-1000-fold higher concentration than required for co-stimulation JJ316 (unlike the clone JJ319 marketed by competitors (see Tacke et al. 1997)) can induce proliferation of all T-cell subsets without TCR engagement.

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu CD28

Target: CD28

Andere Bezeichnung: CD28

Hintergrund: TP44, T-cell-specific surface glycoprotein CD28

UniProt: P31042

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response