ZACN Antikörper (Extracellular, N-Term)

Produktnummer ABIN7887192

Der Kaninchen Polyklonal anti-ZACN Antikörper (ABIN7887192) detektiert spezifisch ZACN in WB, FACS, IC, IF und LCI. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für ZACN Antikörper (Extracellular, N-Term) (ABIN7887192)

Target: ZACN (Zinc Activated Ligand-Gated Ion Channel (ZACN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZACN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunochromatography (IC), Immunofluorescence (IF), Live Cell Imaging (LCI)

Produktdetails anti-ZACN Antikörper

Bindungsspezifität: AA 157-170, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Zinc-Activated Ion Channel

Homologie: Human

Produktmerkmale: Anti-Human ZACN (extracellular) Antibody (ABIN7043880 and ABIN7045343) is a highly specific antibody directed against an epitope of the human Zinc-activated ligand-gated ion channel. The antibody can be used in western blot, immunocytochemistry, and indirect flow cytometry applications. The antibody recognizes an extracellular epitope, and is thus ideal for detecting ZAC in living cells. It has been designed to recognize ZAC from human samples only.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: CNFELLHFPRDHSN, corresponding to amino acid residues 157-170 of human ZACN

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 5 mg per reaction

ICC: 1:25

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu ZACN

Target: ZACN (Zinc Activated Ligand-Gated Ion Channel (ZACN))

Andere Bezeichnung: ZACN

Hintergrund:

Synonyms: Zinc-activated ligand-gated ion channel, Ligand-gated ion channel zinc-activated 1, Ligand-gated ion-channel receptor L2, ZAC, LGICZ1

Description: Over forty homologous proteins belong to the superfamily of ligand-gated ion channels. These members are divided into subfamilies, for example: acetylcholine, serotonin and glycine receptors.A new member has been added to this superfamily - ZAC (Zinc-activated channel) which is expressed in humans and dogs but not in rodents1. Like all other ligand-gated ion channels, ZAC has four transmembrane domains and extracellular N- and C-termini. As its name states, the channel is activated by high concentrations of zinc.ZAC mRNA was found to be expressed in the placenta, spinal cord, stomach, and fetal brain1. In another study, ZAC was identified using a computer-assisted program and was detected in similar areas (including pancreas and kidney), but also displayed minor discrepancies2.Being that the channel is expressed in human and dog, deciphering its cellular/physiological functions will be challenging.

Gen-ID: 353174

NCBI Accession: NM_180990

UniProt: Q401N2

Pathways: Synaptic Membrane