VIPR2 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7887185

Der Kaninchen Polyklonal anti-VIPR2 Antikörper (ABIN7887185) detektiert spezifisch VIPR2 in WB, IF, FACS, IC und LCI. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für VIPR2 Antikörper (Extracellular, N-Term) (ABIN7887185)

Target: VIPR2 (Vasoactive Intestinal Peptide Receptor 2 (VIPR2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VIPR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunochromatography (IC), Live Cell Imaging (LCI)

Produktdetails anti-VIPR2 Antikörper

Bindungsspezifität: AA 25-37, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to VPAC2 Receptor

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,rat - identical

Produktmerkmale: Anti-VPAC2 (VIPR2) (extracellular) Antibody is directed against an extracellular epitope of human VIP and PACAP receptor 2. Anti-VPAC2 (VIPR2) (extracellular) Antibody (ABIN7043877, ABIN7045331 and ABIN7045332) can be used in western blot analysis, immunocytochemistry and indirect flow cytometry applications. It has been designed to recognize VPAC2 from human, rat and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: CRFHLEIQEEETK, corresponding to amino acid residues 25-37 of human VPAC2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:600

FC: 2.5 mg per reaction

ICC: 1:50

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Cited Application: IFC

Negative Control: (ABIN7237559)

Blocking Peptide: (ABIN7237559)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu VIPR2

Target: VIPR2 (Vasoactive Intestinal Peptide Receptor 2 (VIPR2))

Andere Bezeichnung: VIPR2

Hintergrund:

Synonyms: VIP and PACAP receptor 2, Vasoactive intestinal polypeptide receptor 2, Helodermin-preferring VIP receptor, Pituitary adenylate cyclase-activating polypeptide type III receptor, PACAP type III receptor, PACAP-R3

Description: Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) are prominent neuropeptides that are structurally related. Two receptors have similarly high affinity for VIP and PACAP and have therefore been termed VIP and PACAP receptor 1 (VPAC1) and VIP and PACAP receptor 2 (VPAC2). VPAC2 (also known as vasoactive intestinal peptide receptor 2) belongs to the Class II family of G-protein coupled receptors1. A distinct feature of class II GPCRs is the presence of large N-terminal extracellular domains which contain 10 highly conserved amino acids including six cysteines, putative N terminal leader sequences and several potential N-glycosylation sites1.VPAC2 receptor is expressed in the uterus, prostate, smooth muscle of the gastrointestinal tract, seminal vesicles and skin, blood vessels and thymus2. VPAC2 is also expressed in various brain regions including the thalamus and the suprachiasmatic nuclei (SCN)3.VPAC2 plays important roles in the control of mammalian circadian rhythms in the SCN. Mice lacking VPAC2 show altered circadian rhythms in locomotor behavior, neuronal firing and clock gene expression4. Recent studies have also shown that duplication of the VPAC2 gene, and the resulting higher than normal VPAC2 signaling in patients confers a significant risk to schizophrenia5.

Gen-ID: 7434

NCBI Accession: NM_003382

UniProt: P41587

Pathways: cAMP Metabolic Process