SSTR4 Antikörper (2nd Extracellular Loop)

Produktnummer ABIN7887139

Der Kaninchen Polyklonal anti-SSTR4 Antikörper (ABIN7887139) detektiert spezifisch SSTR4 in WB, IHC, IF, FACS und LCI. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte.

Kurzübersicht für SSTR4 Antikörper (2nd Extracellular Loop) (ABIN7887139)

Target: SSTR4 (Somatostatin Receptor 4 (SSTR4))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SSTR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Produktdetails anti-SSTR4 Antikörper

Bindungsspezifität: 2nd Extracellular Loop, AA 182-194

Verwendungszweck: A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 4

Kreuzreaktivität: Maus, Ratte

Homologie: Mouse - identical, human - 12,13 amino acid residues identical

Produktmerkmale: Anti-Somatostatin Receptor Type 4 (extracellular) Antibody (ABIN7043766, ABIN7045265 and ABIN7045266) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize SSTR4 from rat, mouse, and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: DTRPARGGEAVAC, corresponding to amino acid residues 182-194 of rat SSTR4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 2.5 mg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237247)

Blocking Peptide: (ABIN7237247)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu SSTR4

Target: SSTR4 (Somatostatin Receptor 4 (SSTR4))

Andere Bezeichnung: SSTR4

Hintergrund:

Synonyms: SSTR4, SS4R, Smstr4

Description: Somatostatin (SST) is a small cyclic peptide that was first identified as a powerful inhibitor of the secretion of various hormones including growth hormone (GH), thyroid-stimulating hormone (TSH) and prolactin from the pituitary, as well as almost every major hormone from the intestinal tract. SST consists of two major bioactive forms, SST-14 and the N-terminus extended peptide SST-28 that can be produced by a wide variety of neuroendocrine, inflammatory and immune cells. In target cells, SST induces a variety of physiological functions that include neuromodulation, cell secretion, cell proliferation and smooth muscle contractility.SST acts on its multiple cell targets via a family of six receptors that originate from five genes: SSTR1, SSTR2a, SSTR2b, SSTRR3, SSTR4, SSTR5. The SSTRs are members of the G-protein coupled receptor superfamily and they modulate cell responses via multiple second messenger systems such as inhibition of adenylate cyclase, modulation of conductance of ion channels and protein dephosphorylation.SSTRs are expressed widely in both the brain and peripheral tissues but with receptor subtype variations between the different cell types. SSTR4 is the SSTR subtype least expressed in the brain but is most strongly expressed in the lung, heart and placenta.Strong SSTR expression has been detected in a variety of human tumors including pancreatic, breast, lung and prostate cancers. In fact, SST has been shown to inhibit the growth of various normal and tumor cells. On this basis, several long lasting SST analogs have been developed and are being tested for use in several pathologies such as various cancers, acromegaly, immunoproliferative disorders, diabetic retinopathy, epilepsy and pain.

Gen-ID: 25555

NCBI Accession: NM_001052

UniProt: P30937

Pathways: cAMP Metabolic Process