SSTR2 Antikörper (C-Term, Intracellular)

Produktnummer ABIN7887137

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SSTR2 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Ratte.

Kurzübersicht für SSTR2 Antikörper (C-Term, Intracellular) (ABIN7887137)

Target: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SSTR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-SSTR2 Antikörper

Bindungsspezifität: AA 339-359, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 2

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,human - identical

Produktmerkmale: Anti-Somatostatin Receptor Type 2 Antibody (ABIN7043764, ABIN7045263 and ABIN7045264) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize SSTR2 from human, mouse, and rat samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)ERSDSKQDKSRLNETTETQRT corresponding to residues 339-359 of rat SSTR2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237235)

Blocking Peptide: (ABIN7237235)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu SSTR2

Target: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Andere Bezeichnung: SSTR2

Hintergrund:

Synonyms: SSTR2a, SS2R, Smstr2, SRIF1A

Description: Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues1. In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain, it acts as a neurotransmitter in both a stimulatory and an inhibitory manner1,2.Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4, and SSTR5), which are encoded by five genes1,2. Expression of the different receptors is developmentally regulated in a time- and tissue-specific manner2.Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids, and breast tumors3. Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in vivo imaging of tumors that are positive for somatostatin receptors4.In general, SSTR2 is the most common SSTR subtype found in human tumors, followed by SSTR1, with SSTR3 and SSTR4 being less common.

Gen-ID: 54305

NCBI Accession: NM_001050

UniProt: P30680