SCTR Antikörper (Extracellular, N-Term)

Produktnummer ABIN7886420

Der Kaninchen Polyklonal anti-SCTR Antikörper (ABIN7886420) detektiert spezifisch SCTR in WB, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte.

Kurzübersicht für SCTR Antikörper (Extracellular, N-Term) (ABIN7886420)

Target: SCTR (Secretin Receptor (SCTR))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SCTR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-SCTR Antikörper

Bindungsspezifität: AA 129-143, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Secretin Receptor

Kreuzreaktivität: Human, Maus, Ratte

Homologie: 15 amino acid residues identical,Mouse - 14, human - 12

Produktmerkmale: Anti-Secretin Receptor (extracellular) Antibody (ABIN7043607, ABIN7044414 and ABIN7044415) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize SCTR from human, mouse, and rat samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: Peptide (C)NSFNERRHAYLLKLK, corresponding to amino acid residues 129 - 143 of rat Secretin Receptor

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236749)

Blocking Peptide: (ABIN7236749)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu SCTR

Target: SCTR (Secretin Receptor (SCTR))

Andere Bezeichnung: SCTR

Hintergrund:

Synonyms: SCTR

Description: Secretin receptor, SCTR, binds Secretin, a hormone that affects water homeostasis throughout the body and specifically in the duodenum of the small intestine.SCTR is ubiquitously expressed throughout the body. It belongs to class B1 of G-protein coupled receptors, along with vasoactive intestinal polypeptide (VIP) receptor. Like all G-protein coupled receptors, it is composed of seven highly conserved transmembrane domains1. The amino terminus of Secretin receptor plays a key role in agonist recognition and responsiveness2.The binding of SCTR to Secretin initiates a signaling cascade that stimulates bicarbonate secretion which in turn leads to neutralization of gastric H+. This process plays an essential role in fat digestion by creating a more neutral ( pH 6 to 8) environment. Secretin levels are regulated by H+ and fatty acids levels in the duodenum and hence the secretion regulation is tightly bound to its activity3.In addition, SCTR-Secretin interaction plays a major role in the regulation of the secretory activity in the heart, liver and the central nervous system (CNS)3.

Gen-ID: 6344

NCBI Accession: NM_002980

UniProt: P23811