KCNH6 Antikörper (Intracellular)

Produktnummer ABIN7043549

Produktdetails anti-KCNH6 Antikörper

Target: KCNH6 (Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 6 (KCNH6))

Bindungsspezifität: AA 185-198, Intracellular

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNH6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Verwendungszweck: A Rabbit Polyclonal Antibody to KV11.2 (ERG-2) Channel

Spezifität: Intracellular, N-terminal domain

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rat,chicken - identical, mouse - 13,14 amino acid residues identical

Produktmerkmale: Anti-KCNH6 (erg2) Antibody (ABIN7043549 and ABIN7045012) directed against a highly conserved epitope of the human KV11.2 channel. The antibody can be used to detect KV11.2 in rat samples using both western blotting and immunohistochemistry applications.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: TLNFVEFNLEKHRS(C), corresponding to amino acid residues 185-198 of human KV11.2 (erg2)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Kommentare:

Negative Control: (ABIN7236581)

Blocking Peptide: (ABIN7236581)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu KCNH6

Target: KCNH6 (Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 6 (KCNH6))

Andere Bezeichnung: KCNH6 (KCNH6 Produkte)

Hintergrund: KV11.2, Potassium voltage-gated channel subfamily H member 6, Ether-a-go-go-related channel 2, Eag-related protein 2, ERG-2, hERG2,KV11.2 (erg2) is a member of the ether-a-go-go (EAG) subfamily of voltage-dependent K+ channels. The erg subfamily includes the closely related proteins KV11.1 (erg1) and KV11.3 (erg3) that possess the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N- and C-termini. As with all voltage-dependent K+ channels, the functional channel is a tetramer composed of four subunits. It has been suggested that the KV11 subfamily members can form functional heteromultimers within the subfamily.KV11.2 produces currents characterized by strong inward rectification with slow activation and very rapid inactivation kinetics, which closely resemble those produced by the much studied channel KV11.1.The expression of KV11.2 seems to be limited to the brain and the pituitary gland. The same is true for the KV11.3 protein, while KV11.1 is more widely expressed. From a pharmacological point of view, KV11.2 channels can be blocked by well characterized organic blockers such as the anti-arrhythmic drug E-4031. In addition, the peptide toxins Ergtoxin-1 and BeKm-1 block KV11.2 with different potencies.

Alternative names: KCNH6 (erg2), KV11.2, Potassium voltage-gated channel subfamily H member 6, Ether-a-go-go-related channel 2, Eag-related protein 2, ERG-2, hERG2

Gen-ID: 81033

NCBI Accession: NM_030779

UniProt: Q9H252