KCNK1 Antikörper (Extracellular, P1 Loop)

Produktnummer ABIN7886920

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch KCNK1 in WB, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für KCNK1 Antikörper (Extracellular, P1 Loop) (ABIN7886920)

Target: KCNK1 (Potassium Channel Subfamily K Member 1 (KCNK1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-KCNK1 Antikörper

Bindungsspezifität: AA 53-69, Extracellular, P1 Loop

Verwendungszweck: A Rabbit Polyclonal Antibody to KCNK1 Channel

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rat,mouse,pig - identical

Produktmerkmale: Anti-KCNK1 (extracellular) Antibody is directed against an epitope of the human K2P1.1 channel. Anti-KCNK1  (extracellular) Antibody (ABIN7043443, ABIN7045008 and ABIN7045009) can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting KCNK1 in living cells. It has been designed to recognize KCNK1 from mouse, rat and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: RQELRKLKRRFLEEHEC, corresponding to amino acid residues 53-69 of human KCNK1 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200-1:300

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236284)

Blocking Peptide: (ABIN7236284)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu KCNK1

Target: KCNK1 (Potassium Channel Subfamily K Member 1 (KCNK1))

Andere Bezeichnung: KCNK1

Hintergrund:

Synonyms: Potassium channel subfamily K member 1, Inward rectifying K+ channel protein TWIK-1, K2P1.1, HOHO1, KCNO1

Description: KCNK1 (also named TWIK-1 or K2P1.1) is a member of the 2-pore (2P) domain K+ channels family that, currently, includes 16 members. These channels show little time- or voltage-dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini. K2P channels are regulated by diverse physical and chemical stimuli including temperature, pH , mechanical stretch, inhalation anesthetics, etc. but are insensitive to the classical K+ channel blockers.KCNK1 was the first of the K2P channels to be identified and as its original name indicates (Tandem of P domains in a Weak Inward rectifier K+ channel) the channel behaves as a weak inward rectifier when expressed in heterologous systems. The channel is ubiquitously expressed with the most prominent expression in the brain, kidney and heart.

Gen-ID: 3775

NCBI Accession: NM_002245

UniProt: O00180