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nectin-3 Antikörper (Extracellular)

NECTIN3 Reaktivität: Maus WB, IHC, IF (cc), IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7043441
  • Target Alle nectin-3 (NECTIN3) Antikörper anzeigen
    nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))
    Bindungsspezifität
    • 15
    • 10
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 84-97, Extracellular
    Reaktivität
    • 55
    • 38
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 49
    • 7
    • 5
    • 1
    Kaninchen
    Klonalität
    • 52
    • 10
    Polyklonal
    Konjugat
    • 33
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser nectin-3 Antikörper ist unkonjugiert
    Applikation
    • 49
    • 27
    • 13
    • 13
    • 11
    • 8
    • 8
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (IF)
    Verwendungszweck
    A Rabbit Polyclonal Antibody to Nectin-3/PVRL3
    Spezifität
    Extracellular, N-terminus
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Human,rat - identical
    Produktmerkmale
    Anti-Nectin-3/PVRL3 (extracellular) Antibody (ABIN7043441, ABIN7044696 and ABIN7044697)) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot, live cell flow cytometry, and immunohistochemistry applications. It has been designed to recognize Nectin-3 from human, rat, and mouse samples.
    Aufreinigung
    Affinity purified on immobilized antigen.
    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: (C)ETITQISWEKIHGK, corresponding to amino acid residues 84-97 of mouse Nectin-3

    Isotyp
    IgG
    Top Product
    Discover our top product NECTIN3 Primärantikörper
  • Applikationshinweise

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100

    Application Dilutions Western blot wb: 1:200

    Kommentare

    Negative Control: BLP-NR053

    Blocking Peptide: BLP-NR053

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target
    nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))
    Andere Bezeichnung
    NECTIN3 (NECTIN3 Produkte)
    Hintergrund
    Nectin cell adhesion molecule 3, Poliovirus receptor-related 3, CD113,Nectins are Ca2+-independent immunoglobulin-like cell adhesion molecules that localize at adherens junctions between two neighboring cells. They play an important role in mediating asymmetric homotypic and heterotypic cell-cell adhesions. The nectin family contains four members, nectin-1-4, which are encoded by the PVRL1-4 genes, respectively. Nectin-3 is localized mostly in dendrites and partly in axons and is crucial for the specific interactions between axons and dendrites and proper formation of the synapse1,2. Its structure consists of an extracellular region with three immunoglobulin-like loops, one V type and two C2 types.Nectins binds afadin at its c-terminal region and connects to the actin cytoskeleton. This interaction plays a major role in the formation of various cell-cell junctions in cooperation with or independently of cadherins cell adhesion molecules1,2.Nectins also regulates numerous cellular functions, such as cell movement, proliferation, polarization, survival and differentiation by interacting with various proteins1.

    Alternative names: Nectin-3/PVRL3, Nectin cell adhesion molecule 3, Poliovirus receptor-related 3, CD113
    Gen-ID
    58998
    NCBI Accession
    NM_015480
    UniProt
    Q9JLB9
    Pathways
    Cell-Cell Junction Organization
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