Plexin C1 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7887020

Der Kaninchen Polyklonal anti-Plexin C1 Antikörper (ABIN7887020) detektiert spezifisch Plexin C1 in WB, IHC, FACS und LCI. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Plexin C1 Antikörper (Extracellular, N-Term) (ABIN7887020)

Target: Plexin C1 (PLXNC1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Plexin C1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Produktdetails anti-Plexin C1 Antikörper

Bindungsspezifität: AA 860-874, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal antibody to Plexin-C1 (extracellular)

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse - identical Rat - 14 out of 15 amino acid residues identical

Produktmerkmale: A rabbit polyclonal antibody to Plexin-C1 (extracellular)

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)EVKIQKENDNFNISK, corresponding to amino acid residues 860 - 874 of human Plexin-C1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236272)

Blocking Peptide: (ABIN7236272)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Plexin C1

Target: Plexin C1 (PLXNC1)

Andere Bezeichnung: PLXNC1

Hintergrund:

Synonyms: Virus-Encoded Semaphorin Protein Receptor, VESPR, CD232, PLXNC1

Description: Plexin-C1 also known as Virus-encoded semaphorin protein receptor, is a ~210 kDa type I transmembrane receptor that regulates cytoskeletal remodeling and adhesion in human melanocytes.It belongs to the family of Plexin receptors, these are type I transmembrane proteins (A-D) that share a highly conserved cytoplasmic domain and an intracellular region containing an intrinsic Ras-GTPase activating (GAP) domain. Plexin receptors bind semaphorins: a class of secreted and membrane proteins 1. The natural ligand of Plexin C1 is Semaphorin -7A (#ASR-077).Plexin-C1 is highly expressed in melanocytes, neurons, neutrophils, dendritic cells and pre-osteoblasts and it has a complex effect on migration of melanocytes and melanoma, that depends on the phase of progression of this type of cancer 2,3. It also has additional roles in the partitioning of paraventricular and supraoptic neurons in the hypothalamus, in the development of inflamation and in inhibition of neutrophils phagocytosis 3,4.

Gen-ID: 10154

NCBI Accession: NM_005761

UniProt: O60486