Oxytocin Receptor Antikörper (C-Term, Intracellular)

Produktnummer ABIN7887191

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Oxytocin Receptor in WB, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Ratte.

Kurzübersicht für Oxytocin Receptor Antikörper (C-Term, Intracellular) (ABIN7887191)

Target: Oxytocin Receptor (OXTR)

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Oxytocin Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Güteklasse: KO Validated

Produktdetails anti-Oxytocin Receptor Antikörper

Bindungsspezifität: AA 346-358, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Oxytocin Receptor

Kreuzreaktivität: Maus, Ratte

Kreuzreaktivität (Details): Not recommended for use with human samples.

Homologie: Mouse - identical

Produktmerkmale: Anti-Oxytocin Receptor Antibody is directed against an epitope of the rat Oxytocin receptor. Anti-Oxytocin Receptor Antibody (ABIN7043419, ABIN7045341 and ABIN7045342) can be used in western blot analysis. It has been designed to recognize the oxytocin receptor from rat and mouse samples. The antibody is not recommended for use with human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: CSARYLKGSRPGE, corresponding to amino acid residues 346-358 of rat Oxtr

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Cited Application: IP|IHC|ICC

Negative Control: (ABIN7236202)

Blocking Peptide: (ABIN7236202)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Oxytocin Receptor

Target: Oxytocin Receptor (OXTR)

Andere Bezeichnung: OXTR

Hintergrund:

Synonyms: OXTR, OT-R, OTR1

Description: Oxytocin receptor belongs to the class 1 family of G-protein coupled receptors (GPCR) and its role is to regulate reproductive physiology, social and emotional behaviors. Like other members belonging to the GPCR superfamily, it has seven transmembrane domains, extracellular N-terminus and intracellular C-terminal tail1,2.The Oxytocin receptor ligand oxytocin, is a peptide that functions both as a hormone and as a neurotransmitter, and plays an important role in social behavior, estrous cycle, induction of labor and milk ejection, anxiety-related behaviors, food intake, stress-related responses, and pain control. Activation of the receptor leads to the stimulation of phospholipase C by interacting with Gαq/11 in response to ligand binding1.Oxytocin receptor is widely abundant in several brain regions including the basal ganglia, the limbic system, the thalamus, the hypothalamus, the brainstem, and the spinal cord. It is also detected in the uterus, mammary gland, ovary, testis, prostate and kidney.Several studies have suggested that administration of oxytocin in humans has the ability to increase generosity, trust and eye gaze. Oxytocin levels in the plasma relates to parent-child bonding behaviors, feelings of romantic love, trust and empathy. Similarly, Oxytocin receptor knockout mice shows several abnormalities in social and emotional behavior such as increased aggression and deficits in nurturing, positive affection, attachment, sensitivity and social memory2,3.

Gen-ID: 25342

NCBI Accession: NM_000916

UniProt: P70536

Pathways: Myometrial Relaxation and Contraction, Feeding Behaviour