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NTSR2 Antikörper (Intracellular)

Der Kaninchen Polyklonal Anti-NTSR2-Antikörper wurde für WB, IHC, IF und IC validiert. Er ist geeignet, NTSR2 in Proben von Ratte zu detektieren.
Produktnummer ABIN7043384

Kurzübersicht für NTSR2 Antikörper (Intracellular) (ABIN7043384)

Target

Alle NTSR2 Antikörper anzeigen
NTSR2 (Neurotensin Receptor 2 (NTSR2))

Reaktivität

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Ratte

Wirt

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Kaninchen

Klonalität

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  • 1
Polyklonal

Konjugat

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Dieser NTSR2 Antikörper ist unkonjugiert

Applikation

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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)
  • Bindungsspezifität

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    AA 377-392, Intracellular

    Verwendungszweck

    A Rabbit Polyclonal Antibody to Neurotensin Receptor 2

    Spezifität

    Intracellular, C-terminus

    Kreuzreaktivität

    Maus, Ratte

    Kreuzreaktivität (Details)

    Unlikely to recognize human samples.

    Homologie

    Mouse - 14,16 amino acid residues identical

    Produktmerkmale

    Anti-Neurotensin Receptor 2 Antibody is directed against an epitope at the intracellular C-terminal domain of the rat Neurotensin receptor type 2. Anti-Neurotensin Receptor 2 Antibody (ABIN7043384, ABIN7044769 and ABIN7044770) can be used in western blot, immunohistochemical and immunocytochemical applications, and recognizes NTR2 from rat and mouse samples.

    Aufreinigung

    Affinity purified on immobilized antigen.

    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: CGEQHSLVPLPQEAPE, corresponding to amino acid residues 377-392 of rat NTSR2

    Isotyp

    IgG
  • Applikationshinweise

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:50-1:100

    Application Dilutions Western blot wb: 1:200-1:400

    Kommentare

    Cited Application: IHC

    Negative Control: (ABIN7236129)

    Blocking Peptide: (ABIN7236129)

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    0.2 mL double distilled water (DDW).

    Konzentration

    1 mg/mL

    Buffer

    PBS pH 7.4

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target

    NTSR2 (Neurotensin Receptor 2 (NTSR2))

    Andere Bezeichnung

    NTSR2

    Hintergrund

    NTR2, NTSR2, Levocabastine-sensitive neurotensin receptor,Neurotensin receptor 2 (NTR2) is one of three receptors that mediate the effects of the tridecapeptide neurotensin. Neurotensin is synthesized and secreted from neurons in the central neural system (CNS) and from endocrine cells in the gastrointestinal tract.NTR2 and NTR1 belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily while the third neurotensin receptor NTR3 (also called Sortilin) is a type I membrane protein with a large extracellular domain. Both NTR1 and NTR3 bind neurotensin with high affinity while NTR2 binds it with low affinity.1NTR2 signals preferentially through Gaq, resulting in the activation phopholipase C and intracellular Ca2+mobilization. However, the exact signaling mechanisms subsequent to NTR2 activation appear to depend on the species and on the cellular system in which the receptor is studied.NTR2 is expressed mainly in the central nervous system and dorsal root ganglion (DRG) neurons but has been also observed in peripheral tissues such as gastric parietal cells where it probably mediates the neurotensin-induced effects on gastric acid secretion.2The most established physiological role of NTR2 is its role in pain transmission as NTR2-defficient mice showed that NTR2 is the likely mediator of the neurotensin-induced analgesic responses.3

    Alternative names: Neurotensin Receptor 2, NTR2, NTSR2, Levocabastine-sensitive neurotensin receptor

    Gen-ID

    64636

    NCBI Accession

    NM_012344

    UniProt

    Q63384
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