NPY5R Antikörper (3rd Intracellular Loop)

Produktnummer ABIN7886627

Der Kaninchen Polyklonal anti-NPY5R Antikörper wird verwendet zum Nachweis von NPY5R in Proben von Ratte. Er wurde validiert für WB, IHC, IF und IC.

Kurzübersicht für NPY5R Antikörper (3rd Intracellular Loop) (ABIN7886627)

Target: NPY5R (Neuropeptide Y Receptor Y5 (NPY5R))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPY5R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Produktdetails anti-NPY5R Antikörper

Bindungsspezifität: 3rd Intracellular Loop, AA 291-306

Verwendungszweck: A Rabbit Polyclonal Antibody to Neuropeptide Y5 Receptor

Kreuzreaktivität: Maus, Ratte

Homologie: Mouse,bovine,canis - identical, human - 15,16 amino acid residues identical

Produktmerkmale: Anti-NPY5R Antibody is directed against an epitope of the rat neuropeptide Y5 receptor (NPY5R). Anti-NPY5R Antibody (ABIN7043375 and ABIN7044673) can be used in western blot, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize NPY5R from rat, human and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: SFIRKHRRRYSKKTAC, corresponding to amino acid residues 291-306 of rat NPY5R

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:100

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236102)

Blocking Peptide: (ABIN7236102)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu NPY5R

Target: NPY5R (Neuropeptide Y Receptor Y5 (NPY5R))

Andere Bezeichnung: NPY5R

Hintergrund:

Synonyms: Neuropeptide Y5 receptor, Neuropeptide Y receptor type 5, NPY Y5 receptor, NPYY5

Description: Neuropeptide Y (NPY) is a 36 amino acid peptide neurotransmitter present in the central and peripheral nervous systems.1 NPY is involved in the regulation of a broad range of functions such as eating behavior, hypertension, and reproduction.2NPY exerts its effects via five receptor subtypes known as the neuropeptide Y receptors (NPYR): Y1 (NPY1R), Y2 (NPY2R), Y4 (NPY4R), Y5 (NPY5R), and Y6 (NPY6R).2 Four of these (Y1, Y2, Y4, and Y5) are expressed in humans.2 The NPY receptors belong to the G protein-coupled receptor superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Activation of these receptors by NPY affects [Ca2+]i, adenylate cyclase signalling, and a number of ion channel functions.3 Based on their high frequency and density in steroid hormone-producing tumors, the NPYRs might be of potential use in tumor management.2NPY5R as well as NPY1R and NPY2R are expressed in the hypothalamus, in the brain stem, and in peripheral tissues, such as blood vessels, lung, kidney, adrenal glands, stomach, colon, heart, pancreas, and intestine. NPY5R has been postulated as the mediator of the feeding response to NPY and related peptides (125 in Kamiji, M. M). Its localization in the brain is consistent with this hypothesis.4

Gen-ID: 25340

NCBI Accession: NM_006174

UniProt: Q63634

Pathways: Feeding Behaviour