NMUR1 Antikörper (Extracellular)

Produktnummer ABIN7043365

Produktdetails anti-NMUR1 Antikörper

Target: NMUR1 (Neuromedin U Receptor 1 (NMUR1))

Bindungsspezifität: AA 316-331, Extracellular

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NMUR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (Cultured Cells) (IF (cc)), Live Cell Imaging (LCI)

Verwendungszweck: A Rabbit Polyclonal antibody to NMUR1 (extracellular)

Spezifität: Extracellular, 3rd loop.

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Human - 12 out of 16 amino acid residues identical, Mouse - 10 out of 16 amino acid residues identical

Produktmerkmale: A rabbit polyclonal antibody to NMUR1 (extracellular)

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)DRLMWSMVSHWTDGLR, corresponding to amino acid residues 316 - 331 of rat NMUR1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300

Application Dilutions Western blot wb: 1:400-1:500

Kommentare:

Negative Control: BLP-NR071

Blocking Peptide: BLP-NR071

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu NMUR1

Target: NMUR1 (Neuromedin U Receptor 1 (NMUR1))

Andere Bezeichnung: NMUR1 (NMUR1 Produkte)

Hintergrund: Neuromedin-U Receptor 1, G Protein-Coupled Receptor 66, GPR66,Neuromedin U Receptor 1 (NMUR1) is one of the two receptors for the neuropeptide Neuromedin U (NMU). NMUR1 and the second receptor NMUR2 are members of the G protein coupled receptors (GPCRs) superfamily 1.NMU is a neuropeptide with potent activity on smooth muscles that is widely distributed in the gut and central nervous system. NMU interaction with one of its two receptors- NMU1R or NMU2R, mediates the stimulation of smooth muscles, increase of blood pressure, alteration of ion transport in the gut, control of local blood flow and regulation of adrenocortical function1-2.NMU1R is abundantly expressed in peripheral tissues including lung, GI tract, pancreatic islets, testis, adipose, immune tissues, and dorsal root ganglia2, and due to its diverse functions it is a very appealing drug and research candidate.

Alternative names: Neuromedin-U Receptor 1, G Protein-Coupled Receptor 66, GPR66

Gen-ID: 65276

NCBI Accession: NM_006056

UniProt: Q9JJI5