LYNX1 Antikörper (Extracellular)

Produktnummer ABIN7043310

Produktdetails anti-LYNX1 Antikörper

Target: LYNX1 (Ly6/Neurotoxin 1 (LYNX1))

Bindungsspezifität: AA 26-38, Extracellular

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LYNX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (IHC)

Verwendungszweck: A Rabbit Polyclonal Antibody to Lynx1

Spezifität: Extracellular, N-terminus

Kreuzreaktivität: Human, Maus, Ratte

Homologie: rat - 12,Mouse,13 amino acid residues identical, human - 11

Produktmerkmale: Anti-Lynx1 (extracellular) Antibody (ABIN7043310, ABIN7044635 and ABIN7044636)) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot, indirect live cell flow cytometry, and immunohistochemistry applications. It has been designed to recognize Lynx1 from rat, mouse, and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: CAYNGDN(S)FKPMR, corresponding to amino acid residues 26-38 of mouse Lynx1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:1000

Application Dilutions Western blot wb: 1:200

Kommentare:

Negative Control: BLP-NC021

Blocking Peptide: BLP-NC021

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu LYNX1

Target: LYNX1 (Ly6/Neurotoxin 1 (LYNX1))

Andere Bezeichnung: LYNX1 (LYNX1 Produkte)

Hintergrund: Ly-6/Neurotoxin-like protein 1, Endogenous prototoxin LYNX1,Lynx1 is a member of the Ly-6/neurotoxin gene superfamily (Lynx family) of proteins that feature a three-looped toxin fold and a cysteine rich motif, structural characteristics that are shared with the snake venom toxin α-bungarotoxin1.Lynx1 is expressed in large projection neurons in the hippocampus, cortex, and cerebellum. Initial analysis of the functional consequence of genetic ablation of Lynx1 in mice revealed that Lynx1 is an allosteric modulator of various nicotinic receptors that affects their kinetics, decreases their agonist affinities, and increases their desensitization to overall limit their activation. Lynx1 can serve as a protective measure against neurotoxicity through agonist-induced overstimulation2. In fact, deletion of Lynx1 eventually leads to neurodegeneration in aged mice3.Collectively the findings regarding Lynx1 suggest a direct relationship between plasticity regulation and nicotinic signaling, and underline the significance of fine tuning of nicotinic tone to vastly control the development of brain functions.Lynx1 activity was shown to be related to the pathophysiology of Alzheimer's disease as well as cholinergic activity in healthy and tumor cells of bronchial epithelium4.

Alternative names: Ly-6/Neurotoxin-like protein 1, Endogenous prototoxin LYNX1

Gen-ID: 23936

NCBI Accession: NM_177476

UniProt: P0DP60