LRRTM1 Antikörper (Extracellular)

Produktnummer ABIN7043302

Produktdetails anti-LRRTM1 Antikörper

Target: LRRTM1 (Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1))

Bindungsspezifität: AA 334-346, Extracellular

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRRTM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Verwendungszweck: A Rabbit Polyclonal Antibody to LRRTM1

Spezifität: Extracellular, N-terminus

Kreuzreaktivität: Maus, Ratte

Homologie: rat - 12,Mouse,13 amino acid residues identical, human - 11

Produktmerkmale: Anti-LRRTM1 (extracellular) Antibody (ABIN7043302, ABIN7044730 and ABIN7044731)) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It recognizes an extracellular epitope and can potentially detect the protein in living cells. It has been designed to recognize LRRTM1 from human, rat, and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)GRYDANLQ(S)ASPE, corresponding to amino acid residues 334-346 of mouse LRRTM1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:400

Kommentare:

Negative Control: BLP-NR141

Blocking Peptide: BLP-NR141

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu LRRTM1

Target: LRRTM1 (Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1))

Andere Bezeichnung: LRRTM1 (LRRTM1 Produkte)

Hintergrund: Leucine-rich repeat transmembrane neuronal protein 1,Leucine rich repeat transmembrane neuronal 1 (LRRTM1) is a synaptogenic, cell adhesion protein that contributes to the regulation of synapse density and synaptic transmission. The LRRTM family in mammals includes four postsynaptic proteins, which have been shown to interact with presynaptic neurexins and heparan sulphate proteoglycan glypican on the presynaptic side1. In human and mouse genomes, LRRTM1 is encoded by a single exon and is predominantly expressed in the nervous system. LRRTM1 is a single-membrane-spanning transmembrane protein and its structure contains ten N-terminal LRR repeats, a single pass transmembrane domain, and a cytoplasmic C-terminal tail comprising a PDZ-binding motif1.Mutations in human genes encoding the LRRTM proteins are implicated in cognitive disorders. In particular, LRRTM1 is associated to human handedness and schizophrenia1,2. Studies on Lrrtm1 knockout mice shows deficits in behavioral responses to stressful situations and novel objects, spatial memory and social discrimination deficits3. LRRTM1 mutant mice display impairment in visual behaviors, suggesting a functional role of LRRTM1 in retinothalamic convergence in vision4.

Alternative names: LRRTM1, Leucine-rich repeat transmembrane neuronal protein 1

Gen-ID: 74342

NCBI Accession: NM_178839

UniProt: Q8K377

Pathways: Synaptic Membrane