KCNIP1 Antikörper (N-Term)

Produktnummer ABIN7886944

Der Kaninchen Polyklonal anti-KCNIP1 Antikörper (ABIN7886944) detektiert spezifisch KCNIP1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte.

Kurzübersicht für KCNIP1 Antikörper (N-Term) (ABIN7886944)

Target: KCNIP1 (Kv Channel Interacting Protein 1 (KCNIP1))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KCNIP1 Antikörper

Bindungsspezifität: AA 10-21, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to KChIP1 Subunit

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,human - identical

Produktmerkmale: Anti-KChIP1 (KCNIP1) Antibody is directed against an epitope of rat KChIP1. Anti-KChIP1 (KCNIP1) Antibody (ABIN7043295 and ABIN7045039) can be used for western blot analysis. It has been designed to recognize KChIP1 from human mouse and rat samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)SLQTKQRRPSKD, corresponding to amino acid residues 10-21 of rat KChIP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Cited Application: IP

Negative Control: (ABIN7235837)

Blocking Peptide: (ABIN7235837)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu KCNIP1

Target: KCNIP1 (Kv Channel Interacting Protein 1 (KCNIP1))

Andere Bezeichnung: KCNIP1

Hintergrund:

Synonyms: KV channel-interacting protein 1, VABP, Vesicle APC-binding protein, A-type potassium channel modulatory protein 1, Potassium channel-interacting protein 1

Description: Voltage-gated K+ (KV) channels form functional entities by the assembly of four α subunits and auxiliary subunits. Various auxiliary subunits are known to interact with KV channels thereby modulating various properties such as gating, activation and inactivation of the channels as well as influencing trafficking of the channels to the cell's plasma membrane1.KChIPs (KV channel interacting proteins) are cytoplasmic proteins which belong to the neural Ca2+ sensor (NCS) family of Ca2+ binding EF-hand proteins. To date, KChIP1-4 have been identified. All four KChIPs have a conserved C-terminal domain, which has four EF-hand-like Ca2+ binding motifs. The N-terminal region differs among the various KChIPs and attributes different properties regarding the regulation of KV channels1. KChIPs regulate different properties of KV channels such as their cell surface expression (mediated by proper trafficking of the various subunits), channel assembly and gating1-4. Specifically, KChIP1 strongly regulates the activity of the KV4 channel family1. KChIP1 has also been found to assist GABA-mediated IPSCs (inhibitory postsynaptic currents) by increasing the release of presynaptic transmitter5. Furthermore, KChIP knockout mice display an increase in anxiety-like behavior compared to their wild type counterparts5.KChIP1, 3, and 4 are mostly expressed in the brain while KChIP2 is expressed in the heart as well as in the brain4-6.

Gen-ID: 65023

NCBI Accession: NM_001278339

UniProt: Q8R426