GSG1-Like Antikörper (C-Term, Intracellular)

Produktnummer ABIN7886407

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GSG1-Like in IHC, WB und IF. Es zeigt Reaktivität gegenüber Proben von Ratte.

Kurzübersicht für GSG1-Like Antikörper (C-Term, Intracellular) (ABIN7886407)

Target: GSG1-Like (GSG1L)

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GSG1-Like Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-GSG1-Like Antikörper

Bindungsspezifität: AA 283-295, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to GSG1L

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse - identical, human - 12,13 amino acid residues identical

Produktmerkmale: Anti-GSG1L Antibody (ABIN7043266, ABIN7044390 and ABIN7044391) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize GSG1L from human, rat, and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: CRHERYPTRHQPH, corresponding to amino acid residues 283 - 295 of rat GSG1L

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235743)

Blocking Peptide: (ABIN7235743)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu GSG1-Like

Target: GSG1-Like (GSG1L)

Andere Bezeichnung: GSG1L

Hintergrund:

Synonyms: Germ cell-specific gene 1-like protein, GSG1-like protein

Description: Germline-specific gene 1-like (GSG1L) is a tetra-spanning membrane protein which belongs to the Claudin protein superfamily. It acts as an auxiliary subunit that modulates the assembly, trafficking and gating of AMPA receptors (AMPAR)1.GSG1L has four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm, the juxtamembrane region in its C-tail extracellular Loop1 domain is critical for its suppression of AMPAR-mediated synaptic transmission2.AMPA receptors are ligand gated ion channels critical for synaptic transmission and plasticity. Their dysfunction is involved in a variety of psychiatric and neurological diseases ranging from major depressive disorder to amyotrophic lateral sclerosis. A newly explored strategy is to manipulate the activity of AMPA receptors is through compounds that affect specific AMPAR-auxiliary subunit complexes. Overexpression of GSG1L strongly suppresses AMPAR, and GSG1L knockout enhances AMPAR-mediated synaptic transmission which makes it a leading therapeutic candidate for manipulating AMPAR activity3.

Gen-ID: 499263

NCBI Accession: NM_144675

UniProt: D3ZK93