Metabotropic Glutamate Receptor 4 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7886376

Der Kaninchen Polyklonal anti-Metabotropic Glutamate Receptor 4 Antikörper wird verwendet zum Nachweis von Metabotropic Glutamate Receptor 4 in Proben von Ratte. Er wurde validiert für WB, IF, IC und LCI.

Kurzübersicht für Metabotropic Glutamate Receptor 4 Antikörper (Extracellular, N-Term) (ABIN7886376)

Target: Metabotropic Glutamate Receptor 4 (GRM4) (Glutamate Receptor, Metabotropic 4 (GRM4))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Metabotropic Glutamate Receptor 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Produktdetails anti-Metabotropic Glutamate Receptor 4 Antikörper

Bindungsspezifität: AA 33-44, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Metabotropic Glutamate Receptor 4

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,human - identical

Produktmerkmale: Anti-mGluR4 (extracellular) Antibody is directed against an extracellular epitope of rat mGluR4. Anti-mGluR4 (extracellular) Antibody (ABIN7043249, ABIN7044344 and ABIN7044345) can be used in western blot and live cell imaging applications. It has been designed to recognize mGluR4 from rat, mouse and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: KPKGHPHMNSIR(C), corresponding to amino acid residues 33-44 of rat mGluR4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:50

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235693)

Blocking Peptide: (ABIN7235693)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Metabotropic Glutamate Receptor 4

Target: Metabotropic Glutamate Receptor 4 (GRM4) (Glutamate Receptor, Metabotropic 4 (GRM4))

Andere Bezeichnung: GRM4

Hintergrund:

Synonyms: Metabotropic glutamate receptor 4, GRM4, mGlu4, GPRC1D

Description: Metabotropic glutamate receptors (mGluRs) belong to the super family of G-protein coupled receptors (seven transmembrane proteins). mGluRs are further divided into subfamilies: group I mGluRs (mGluR1 and mGluR5) which couple to Gq, thereby activating phospholipase C (PLC). Group II which include mGluR2 and mGluR3 couple to Gi, therefore inhibit the formation of adenylate cyclase. mGluR4, 6, 7, 8 which belong to group III also inhibit adenylate cyclase formation by coupling to Gi1.The C-terminus of these receptors has important functions in modulating their activity. This region is important for G-protein coupling, post-translational modifications like phosphorylation as well as protein-protein interactions. The C-terminal region is also subject to alternative splicing2.mGluR4 is predominantly expressed presynaptically in neurons and in the cerebellum. A splice variant of the protein is expressed in taste buds. This variant lacks a large portion of the N-terminus and is normally referred to taste mGluR43,4. It is responsible (along with taste mGluR1) for mediating the taste of monosodium glutamate (or unami)2,4.mGluR4 knock out mice display impaired cerebellar synaptic plasticity as well as some learning disabilities5. In addition, this receptor has emerged as a target for the treatment of Parkinson's disease6.

Gen-ID: 24417

NCBI Accession: NM_000841

UniProt: P31423