GRIP1 Antikörper (C-Term, Intracellular)

Produktnummer ABIN7887042

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GRIP1 in WB. Es zeigt Reaktivität gegenüber Proben von Ratte.

Kurzübersicht für GRIP1 Antikörper (C-Term, Intracellular) (ABIN7887042)

Target: GRIP1 (Glutamate Receptor Interacting Protein 1 (GRIP1))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GRIP1 Antikörper

Bindungsspezifität: AA 963-977, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to GRIP1

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,human - identical

Produktmerkmale: Anti-GRIP1 Antibody (ABIN7043227, ABIN7045158 and ABIN7045159) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize GRIP1 from human, mouse, and rat samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RKSVTLRKMKQEIKE, corresponding to amino acid residues 963-977 of rat GRIP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235622)

Blocking Peptide: (ABIN7235622)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu GRIP1

Target: GRIP1 (Glutamate Receptor Interacting Protein 1 (GRIP1))

Andere Bezeichnung: GRIP1

Hintergrund:

Synonyms: Glutamate receptor interacting protein 1

Description: GRIP1 (glutamate receptor interacting protein 1) is a neuron-enriched scaffolding protein that plays an important role in regulating synaptic trafficking, synaptic strength and synaptic organization and transmission of AMPA receptor 2 and 3 (GluA2/3) 1,2. GRIP1 structure contains 7 PDZ domains responsible for protein-protein interactions. GRIP1 forms homodimers that can bind and simultaneously organize and assemble protein complexes via PDZ domains1,2.GRIP1 is abundantly expressed in glutamatergic and GABAergic synapses. In addition, GRIP1 expression can be found in muscle cells and in the epidermis1,3. Studies on GRIP1 knockout mice have revealed multi-organ developmental abnormalities. These mice die due to hemorrhage and hypovolemia in the embryonic or early post-natal period2.Mutations in GRIP1 protein resulting in a gain-of-function phenotype are linked to autism, while neuronal-specific loss-of-function mice have prosocial behavior. Other point mutations have been associated with schizophrenia and congenital kidney disease2,3.

Gen-ID: 84016

NCBI Accession: NM_001178074

UniProt: P97879

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway