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FZD3 Antikörper (Intracellular)

FZD3 Reaktivität: Maus WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7043142
  • Target Alle FZD3 Antikörper anzeigen
    FZD3 (Frizzled Family Receptor 3 (FZD3))
    Bindungsspezifität
    • 8
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 581-596, Intracellular
    Reaktivität
    • 40
    • 19
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 34
    • 4
    • 3
    • 2
    Kaninchen
    Klonalität
    • 37
    • 6
    Polyklonal
    Konjugat
    • 29
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FZD3 Antikörper ist unkonjugiert
    Applikation
    • 34
    • 25
    • 12
    • 11
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Verwendungszweck
    A Rabbit Polyclonal antibody to Frizzled-3 receptor.
    Spezifität
    Intracellular, C-terminus.
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Human,rat - identical
    Produktmerkmale
    A rabbit polyclonal antibody to Frizzled-3 receptor.
    Aufreinigung
    Affinity purified on immobilized antigen.
    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: Peptide (C)KVSSYHGSLHRSRDGR, corresponding to amino acid residues 581 - 596 of mouse Frizzled-3

    Isotyp
    IgG
    Top Product
    Discover our top product FZD3 Primärantikörper
  • Applikationshinweise

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

    Application Dilutions Western blot wb: 1:200

    Kommentare

    Negative Control: (ABIN7235344)

    Blocking Peptide: (ABIN7235344)

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    0.2 mL double distilled water (DDW).
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target
    FZD3 (Frizzled Family Receptor 3 (FZD3))
    Andere Bezeichnung
    FZD3 (FZD3 Produkte)
    Hintergrund
    Frizzled Class Receptor 3, Fz-3,Frizzled 3, encoded by FZD3 gene, is a receptor in the Wnt/β-catenin pathway, a conserved signaling pathway that regulates gene expression and controls diverse developmental processes 1. It belongs to the Frizzled protein family that contains multiple hydrophobic domains predicted to form seven transmembrane helices, similar to G protein coupled receptors. Conserved sequences are found in the Frizzled proteins extracellular cysteine-rich domain (CRD), the putative transmembrane domains, parts of the intracellular loops and a juxtamembrane motif, KTXXXW, found in the membrane-proximal C-terminal region of all Frizzleds. The C-terminal tails, however, are highly divergent 2. Frizzled-3 is constitutively expressed in murine melanocyte precursors, melanocytes and human melanocytes 3, it is also expressed in the epidermis of the developing embryo 4 and its expression levels are changing between different parts of the ovary throughout the process of embryogenesis 1. Because of its crucial role in regulating proper embryogenesis and its role in the development of the central nervous system, including synaptogenesis and structural plasticity, mutations in FZD3 gene were shown to have a significant association with the development of schizophrenia and other psychotic disorders 5.

    Alternative names: Frizzled Class Receptor 3, Fz-3
    Gen-ID
    14365
    NCBI Accession
    NM_145866
    UniProt
    Q61086
    Pathways
    WNT Signalweg, Tube Formation
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