FZD3 Antikörper (Intracellular)
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- Target Alle FZD3 Antikörper anzeigen
- FZD3 (Frizzled Family Receptor 3 (FZD3))
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Bindungsspezifität
- AA 581-596, Intracellular
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Reaktivität
- Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FZD3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Verwendungszweck
- A Rabbit Polyclonal antibody to Frizzled-3 receptor.
- Spezifität
- Intracellular, C-terminus.
- Kreuzreaktivität
- Human, Maus, Ratte
- Homologie
- Human,rat - identical
- Produktmerkmale
- A rabbit polyclonal antibody to Frizzled-3 receptor.
- Aufreinigung
- Affinity purified on immobilized antigen.
- Immunogen
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Immunogen: Synthetic peptide
Immunogen Sequence: Peptide (C)KVSSYHGSLHRSRDGR, corresponding to amino acid residues 581 - 596 of mouse Frizzled-3
- Isotyp
- IgG
- Top Product
- Discover our top product FZD3 Primärantikörper
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- Applikationshinweise
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200
- Kommentare
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Negative Control: (ABIN7235344)
Blocking Peptide: (ABIN7235344)
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- 0.2 mL double distilled water (DDW).
- Konzentration
- 1 mg/mL
- Buffer
- PBS pH 7.4
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Target
- FZD3 (Frizzled Family Receptor 3 (FZD3))
- Andere Bezeichnung
- FZD3 (FZD3 Produkte)
- Hintergrund
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Frizzled Class Receptor 3, Fz-3,Frizzled 3, encoded by FZD3 gene, is a receptor in the Wnt/β-catenin pathway, a conserved signaling pathway that regulates gene expression and controls diverse developmental processes 1. It belongs to the Frizzled protein family that contains multiple hydrophobic domains predicted to form seven transmembrane helices, similar to G protein coupled receptors. Conserved sequences are found in the Frizzled proteins extracellular cysteine-rich domain (CRD), the putative transmembrane domains, parts of the intracellular loops and a juxtamembrane motif, KTXXXW, found in the membrane-proximal C-terminal region of all Frizzleds. The C-terminal tails, however, are highly divergent 2. Frizzled-3 is constitutively expressed in murine melanocyte precursors, melanocytes and human melanocytes 3, it is also expressed in the epidermis of the developing embryo 4 and its expression levels are changing between different parts of the ovary throughout the process of embryogenesis 1. Because of its crucial role in regulating proper embryogenesis and its role in the development of the central nervous system, including synaptogenesis and structural plasticity, mutations in FZD3 gene were shown to have a significant association with the development of schizophrenia and other psychotic disorders 5.
Alternative names: Frizzled Class Receptor 3, Fz-3 - Gen-ID
- 14365
- NCBI Accession
- NM_145866
- UniProt
- Q61086
- Pathways
- WNT Signalweg, Tube Formation
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