PIEZO2 Antikörper (Internal Region)

Produktnummer ABIN7886910

Der Kaninchen Polyklonal anti-PIEZO2 Antikörper (ABIN7886910) detektiert spezifisch PIEZO2 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PIEZO2 Antikörper (Internal Region) (ABIN7886910)

Target: PIEZO2 (FAM38B) (Family with Sequence Similarity 38, Member B (FAM38B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIEZO2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Güteklasse: KO Validated

Produktdetails anti-PIEZO2 Antikörper

Bindungsspezifität: AA 1092-1104, Internal Region

Verwendungszweck: A Rabbit Polyclonal Antibody to Piezo2

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,rat - 12,13 amino acid residues identical

Produktmerkmale: Anti-Piezo2 Antibody (ABIN7043133, ABIN7044990 and ABIN7044991) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot analysis. It has been designed to recognize Piezo2 from human, rat, and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RTIFHDITRLHLD, corresponding to amino acid residues 1092 - 1104 of human Piezo2 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Cited Application: IP|IHC|ICC|Whole Tissue Staining

Negative Control: (ABIN7235322)

Blocking Peptide: (ABIN7235322)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu PIEZO2

Target: PIEZO2 (FAM38B) (Family with Sequence Similarity 38, Member B (FAM38B))

Andere Bezeichnung: PIEZO2

Hintergrund:

Synonyms: Piezo-Type Mechanosensitive Ion Channel Component 2, Protein FAM38B

Description: Piezo-type mechanosensitive ion channel component 2 (Piezo2) is a homotrimeric ion channel. Piezo2 depicts rapidly adapting mechanically activated (MA) currents in somatosensory neurons.Piezo1 and Piezo2 comprise the Piezo protein family. These are large transmembrane proteins are conserved among various species, and all have between 24 and 36 predicted transmembrane domains. Both channels open in response to mechanical stimuli, allowing positively charged ions, including calcium, to flow into the cell1.Piezo2 protein contains over 2,800 residues, it forms a three-bladed, propeller like trimer that comprises 114 transmembrane helices (38 per protomer). Transmembrane helices 1-36 (TM1-36) are folded into nine tandem units of four transmembrane helices each to form the unusual non-planar blades2.Piezo2 has an essential role in sensing gentle touch, tactile pain, airway stretch and lung inflation. It also serves as a baroreceptor for sensing blood pressure and regulating heart rate. Mutations in human Piezo2 are associated with distal arthrogryposis, a disorder characterized by joint deformities (contractures) that restrict movement in the hands and feet3,4.

Gen-ID: 63895

NCBI Accession: NM_022068

UniProt: Q9H5I5