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DRD3 Antikörper (Extracellular)

Dieses Anti-DRD3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DRD3 in WB, IHC, IF, FACS und LCI. Geeignet für Ratte.
Produktnummer ABIN7043109

Kurzübersicht für DRD3 Antikörper (Extracellular) (ABIN7043109)

Target

Alle DRD3 Antikörper anzeigen
DRD3 (Dopamine Receptor D3 (DRD3))

Reaktivität

  • 54
  • 32
  • 31
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Ratte

Wirt

  • 53
  • 4
Kaninchen

Klonalität

  • 49
  • 8
Polyklonal

Konjugat

  • 31
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser DRD3 Antikörper ist unkonjugiert

Applikation

  • 47
  • 15
  • 13
  • 13
  • 12
  • 9
  • 6
  • 5
  • 3
  • 3
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Güteklasse

KO Validated
  • Bindungsspezifität

    • 15
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 15-29, Extracellular

    Verwendungszweck

    A Rabbit Polyclonal Antibody to D3 Dopamine Receptor

    Spezifität

    Extracellular, N-terminus

    Kreuzreaktivität

    Maus, Ratte

    Homologie

    Mouse - identical, human - 12,15 amino acid residues identical

    Produktmerkmale

    Anti-D3 Dopamine Receptor (extracellular) Antibody is directed against an epitope located at the extracellular N-terminus of the rat D3 dopamine receptor. Anti-D3 Dopamine Receptor (extracellular) Antibody (ABIN7043109, ABIN7044231 and ABIN7044232) can be used in western blot analysis and immunohistochemical applications, and recognizes DRD3 from rat and mouse samples.

    Aufreinigung

    Affinity purified on immobilized antigen.

    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: CGAENSTGVNRARPH, corresponding to amino acid residues 15-29 of rat DRD3 

    Isotyp

    IgG
  • Applikationshinweise

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100

    Application Dilutions Western blot wb: 1:200

    Kommentare

    Cited Application: IHC|IFC

    Negative Control: (ABIN7235243)

    Blocking Peptide: (ABIN7235243)

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

    Konzentration

    1 mg/mL

    Buffer

    PBS pH 7.4

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target

    DRD3 (Dopamine Receptor D3 (DRD3))

    Andere Bezeichnung

    DRD3

    Hintergrund

    DRD3,The D3 Dopamine Receptor (D3 receptor) is one of five receptors that mediate the effects of the catecholamine neurotransmitter dopamine. Dopamine regulates a variety of functions including locomotor activity, emotion, positive reinforcement, food intake, and endocrine regulation. The dopaminergic system has been extensively studied in the last thirty years mainly because its dysregulation has been linked to several neurological and neuropsychiatric diseases including Parkinson's disease and schizophrenia.1All five dopamine receptors belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.Historically, the five receptors have been divided into two subfamilies based on pharmacological and structural considerations: the D1-like subfamily (that includes the D1 and D5 subtypes) and the D2-like subfamily (that includes the D2-, D3- and D4 subtypes).1The D1-like receptors are coupled to Gs-type G proteins and enhance adenylate cyclase activity while the D2-like receptors are coupled to Gi-type G proteins and inhibit adenylate cyclase activity.1The D3 receptor distribution in the brain is relatively restricted to limbic areas such as striatum, islands of Calleja and olfactory tubercle. In the periphery, it is expressed in the kidney particularly in proximal tubules.1The exact physiological function of the D3 receptor remains to be fully elucidated. In studies using D3 receptor knockout mice, the most prominent dysfunction was the development of rennin-dependent hypertension. Potential roles in reinforcement and reward behaviors have also been suggested as well as roles in neuropsychiatric disorders such as drug abuse and schizophrenia.2

    Alternative names: D3 Dopamine Receptor, DRD3

    Gen-ID

    29238

    NCBI Accession

    NM_000796

    UniProt

    P19020

    Pathways

    Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Proton Transport, Negative Regulation of Transporter Activity
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