CNGA2 Antikörper (C-Term, Intracellular)

Produktnummer ABIN7886879

Der Kaninchen Polyklonal anti-CNGA2 Antikörper wird verwendet zum Nachweis von CNGA2 in Proben von Ratte. Er wurde validiert für WB, IHC, IF und IC.

Kurzübersicht für CNGA2 Antikörper (C-Term, Intracellular) (ABIN7886879)

Target: CNGA2 (Cyclic Nucleotide Gated Channel alpha 2 (CNGA2))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CNGA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Produktdetails anti-CNGA2 Antikörper

Bindungsspezifität: AA 643-660, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to CNGA2 Channel

Kreuzreaktivität: Human, Maus, Ratte

Homologie: rabbit - 15,18 amino acid residues identical, human,bovine - 14,Mouse - identical

Produktmerkmale: Anti-CNGA2 Antibody is directed against an intracellular epitope of the rat CNGA2 channel. Anti-CNGA2 Antibody (ABIN7043090, ABIN7044955 and ABIN7044956) can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize CNGA2 from human, rat, and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)KQNHEDDYLSDGINTPEP, corresponding to amino acid residues 643-660 of rat CNGA2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Kommentare:

Cited Application: IHC|ICC

Negative Control: (ABIN7235185)

Blocking Peptide: (ABIN7235185)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu CNGA2

Target: CNGA2 (Cyclic Nucleotide Gated Channel alpha 2 (CNGA2))

Andere Bezeichnung: CNGA2

Hintergrund:

Synonyms: Cyclic nucleotide-gated cation channel 2, CNG channel alpha-2, CNG2, CNCG2, Olfactory cyclic nucleotide gated channel 1, OCNC1

Description: Cyclic nucleotides are important second messengers in many cellular functions such as visual transduction, and relaxation of smooth muscle cells. Cyclic nucleotides exert their cellular functions through three major classes of cellular receptors, one of them is the cyclic nucleotide-gated (CNG) channels.1 The CNG channels are non-selective cation channels facilitating the influx of Na+ and Ca2+ ions, following activation by intracellular cyclic nucleotides.2 In vertebrates, six members of the CNG channel family were identified and grouped according to sequence homology into two subtypes, CNGA and CNGB. To date, four types of the a subunits (CNGA1-4) and two b subunits (CNGB1, CNGB3) have been characterized.3 Native CNG channels are composed of a and b subunits in a tetrameric configuration. Each subunit contains 6 TM domains and intracellular cAMP or cGMP binding domains, but are also modulated by other factors including phosphorylation and calmodulin.4 In a heterologous expression system, only the a subunits are capable of forming functional homomeric channels. CNG ion channels are essential in visual and olfactory signal transduction.CNG channels were originally detected in rod and cone photoreceptors and olfactory receptor cells, where they mediate the transduction of external sensory stimuli into neuronal activity.5CNGA2 is predominantly expressed in olfactory neurons (the olfactory type receptor). However, electrophysiological and molecular data indicate that CNGA1, and especially CNGA2, are widely distributed and functionally active in many regions of the brain, including the hippocampus, cerebral cortex, cerebellum, and brainstem.6

Gen-ID: 108348053

NCBI Accession: NM_005140

UniProt: Q00195