CNTNAP2 Antikörper (Intracellular)

Produktnummer ABIN7043084

Produktdetails anti-CNTNAP2 Antikörper

Target: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Bindungsspezifität: AA 1315-1331, Intracellular

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CNTNAP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Verwendungszweck: A Rabbit Polyclonal Antibody to Caspr2

Spezifität: Intracellular, C-terminus

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,rat - identical

Produktmerkmale: Anti-Caspr2 Antibody is directed against an epitope of human Caspr2. Anti-Caspr2 Antibody (ABIN7043084, ABIN7045145 and ABIN7045146)) can be used in western blot and immunohistochemistry analysis. It has been designed to recognize Caspr2 from rat, mouse and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)DPNFTETIDESKKEWLI, corresponding to amino acid residues 1315-1331 of human Caspr2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:200

Kommentare:

Negative Control: BLP-PZ005

Blocking Peptide: BLP-PZ005

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu CNTNAP2

Target: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Andere Bezeichnung: CNTNAP2 (CNTNAP2 Produkte)

Hintergrund: Contactin-associated protein-like 2, CNTNAP2,Contactin-associated protein 2 (Caspr2) is a member of the neurexin superfamily, a group of transmembrane proteins that mediate cell-to-cell interactions in the nervous system1,2.Neurexins are adhesion molecules expressed mainly at presynaptic locations that form trans-synaptic cell-to-cell adhesion complexes via binding to their postsynaptic partners, the neuroligins2.Caspr2, like other neurexin proteins, is a type I membrane protein that contains epidermal growth factor repeats, laminin G domains, an F5/8 type C domain, and fibrinogen-like domains in its extracellular domain1,2.Caspr2 is localized at the juxtaparanodes of myelinated axons, a specialized region that mediates interactions between neurons and glia during nervous system development1.The juxtaparanodal region is highly enriched with heteromultimers of the K+ channels KV1.1, KV1.2, and their cytoplasmic KVβ2 subunit, which may help in axon conduction stabilization and the maintenance of the internodal resting potential1. Caspr2 is essential for the targeted localization of these channels in the juxtaparanodal regions. Indeed, targeted disruption of Caspr2 resulted in a marked reduction in the accumulation of K+ channels at the juxtaparanodes in both peripheral and central nervous system axons3.Moreover, mutations in the Caspr2 gene have been implicated in multiple neurodevelopmental disorders, including Tourette syndrome, schizophrenia, epilepsy, autism, attention-deficit hyperactivity disorder and mental retardation4-6.

Alternative names: Caspr2, Contactin-associated protein-like 2, CNTNAP2

Gen-ID: 26047

NCBI Accession: NM_014141

UniProt: Q9UHC6