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CRMP1 Antikörper (Intracellular)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CRMP1 in WB. Er zeigt eine Reaktivität gegenüber Ratte.
Produktnummer ABIN7043080

Kurzübersicht für CRMP1 Antikörper (Intracellular) (ABIN7043080)

Target

Alle CRMP1 Antikörper anzeigen
CRMP1 (Collapsin Response Mediator Protein 1 (CRMP1))

Reaktivität

  • 56
  • 34
  • 29
  • 5
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
Ratte

Wirt

  • 55
  • 1
Kaninchen

Klonalität

  • 46
  • 10
Polyklonal

Konjugat

  • 31
  • 5
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Dieser CRMP1 Antikörper ist unkonjugiert

Applikation

  • 38
  • 25
  • 12
  • 10
  • 5
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 8
    • 7
    • 7
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 481-496, Intracellular

    Verwendungszweck

    A Rabbit Polyclonal Antibody to CRMP-1

    Spezifität

    Intracellular

    Kreuzreaktivität

    Human, Maus, Ratte

    Homologie

    Mouse - identical, human - 12,16 amino acid residues identical

    Produktmerkmale

    Anti-CRMP1 Antibody (ABIN7043080, ABIN7044540 and ABIN7044541) is a highly selective antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize from human, mouse, and rat samples.

    Aufreinigung

    Affinity purified on immobilized antigen.

    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: (C)RVRIRSKVFGLHSVSR, corresponding to amino acid residues 481-496 of rat CRMP1

    Isotyp

    IgG
  • Applikationshinweise

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

    Application Dilutions Western blot wb: 1:200

    Kommentare

    Negative Control: (ABIN7235158)

    Blocking Peptide: (ABIN7235158)

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

    Konzentration

    1 mg/mL

    Buffer

    PBS pH 7.4

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target

    CRMP1 (Collapsin Response Mediator Protein 1 (CRMP1))

    Andere Bezeichnung

    CRMP1

    Hintergrund

    CRMP-1, Collapsin response mediator protein 1, Dihydropyrimidinase-related protein 1, DRP-1, Dpysl1, Dihydropyrimidinase-like 1, Ulip3, Unc-33-like phosphoprotein 3,Collapsin response mediator proteins (CRMPs) are a family of cytosolic phosphoproteins that were originally identified in developing nervous tissue. They are characterized as intracellular mediators of Semaphorin 3A signaling pathway, which is involved in axon differentiation during neural development.The CRMP family includes five members, CRMP-1 to CRMP-5. All five isoforms share a significant similarity in sequence with liver dihydropyrimidinase (DHPase) and with each other. CRMP-1 to CRMP-4 share 75 % identical sequence, while CRMP-5 shares 50 % identity with the other CRMPs.CRMP-1 is involved in cortical neuronal migration through reelin signaling. CRMP-1 inhibits the migration and invasion of non-small cell lung cancer (NSCLC). CRMP-1 includes a long form isoform, LCRMP-1, which promotes filopodia formation, cancer cell migration and invasion, resulting in poor clinical outcomes in NSCLC patients, therefore the long form is considered to be an invasion enhancer in NSCLC1-3.Human CRMP-1 overall structure is very similar to mouse CRMP-1. The human protein generally comprises a heterotetrameric assembly with a randomly coiled link that connects the protomers to each other. The proteins can form homotetramers when purified from bovine brain. CRMPs contains a positively charged C-terminal region that is highly susceptible to proteolysis2,3.

    Alternative names: CRMP1, CRMP-1, Collapsin response mediator protein 1, Dihydropyrimidinase-related protein 1, DRP-1, Dpysl1, Dihydropyrimidinase-like 1, Ulip3, Unc-33-like phosphoprotein 3

    Gen-ID

    25415

    NCBI Accession

    NM_001313

    UniProt

    Q62950
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