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CHERP Antikörper (Cytosolic)

CHERP Reaktivität: Maus WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7043011
  • Target Alle CHERP Antikörper anzeigen
    CHERP (Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP))
    Bindungsspezifität
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 669-684, Cytosolic
    Reaktivität
    • 32
    • 11
    • 8
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Maus
    Wirt
    • 30
    • 4
    Kaninchen
    Klonalität
    • 32
    • 2
    Polyklonal
    Konjugat
    • 20
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CHERP Antikörper ist unkonjugiert
    Applikation
    • 25
    • 13
    • 5
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Verwendungszweck
    A Rabbit Polyclonal Antibody to CHERP
    Spezifität
    Cytoplasmic
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Rat,human - identical
    Produktmerkmale
    Anti-CHERP Antibody (ABIN7043011, ABIN7044119 and ABIN7044120) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize CHERP from human, rat, and mouse samples.
    Aufreinigung
    Affinity purified on immobilized antigen.
    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: (C)KLEDHEYKPLDPKDIR, corresponding to amino acid residues 669-684 of mouse CHERP

    Isotyp
    IgG
    Top Product
    Discover our top product CHERP Primärantikörper
  • Applikationshinweise

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

    Application Dilutions Western blot wb: 1:1500

    Kommentare

    Negative Control: (ABIN7235001)

    Blocking Peptide: (ABIN7235001)

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target
    CHERP (Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP))
    Andere Bezeichnung
    CHERP (CHERP Produkte)
    Hintergrund
    Calcium homeostasis endoplasmic reticulum protein, SR-related CTD-associated factor 6, SCAF6,CHERP (calcium homeostasis endoplasmic reticulum protein) is a ubiquitously expressed integral sarco/endoplasmic reticulum (SR/ER) membrane protein. CHERP protein consist of 916 amino acid in humans and its structure containing a Pro-rich region and a segment of Arg-Ser dipeptide repeats (an RS domain) near the C terminus, and an RNA recognition motifs (RRMs)1-3.CHERP acts as a regulator of both major families of endoplasmic reticulum Ca2+ channels, inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs). CHERP is responsible for the regulation of intracellular Ca2+ mobilization in human cells and is involved in neuroblastoma cell proliferation, apoptosis and tumorigenicity1,2.CHERP co-localizes with IP3 receptors throughout the cytoplasmic and perinuclear regions in human erythroleukemia cells and in Jurkat cells. CHERP is also detected in the nucleoplasm with prominent accumulation at nuclear speckles1,2. CHERP co-localizes with endogenous ryanodine receptor type 1 (RyR1) in the sarcoplasmic reticulum of rat soleus muscle. Studies of CHERP knockdown reveal decreased intracellular Ca2+ mobilization, cell growth and proliferation2,3.

    Alternative names: CHERP, Calcium homeostasis endoplasmic reticulum protein, SR-related CTD-associated factor 6, SCAF6
    Gen-ID
    27967
    NCBI Accession
    NM_006387
    UniProt
    Q8CGZ0
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