Astrotactin 1 (ASTN1) (AA 1068-1080), (C-Term), (Extracellular) Antikörper

Produktnummer ABIN7886677

Der Kaninchen Polyklonal anti-Astrotactin 1 Antikörper wird verwendet zum Nachweis von Astrotactin 1 in Proben von Maus. Er wurde validiert für WB, IF und IHC.

Kurzübersicht für Astrotactin 1 (ASTN1) (AA 1068-1080), (C-Term), (Extracellular) Antikörper (ABIN7886677)

Target: Astrotactin 1 (ASTN1)

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Produktdetails

Bindungsspezifität: AA 1068-1080, C-Term, Extracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Astrotactin-1

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rat,human - identical

Produktmerkmale: Anti-ASTN1 (extracellular) Antibody (ABIN7042949, ABIN7044732 and ABIN7044733) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Astrotactin-1 from rat, mouse, and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RQEKVTDRMDHSK, corresponding to amino acid residues 1068-1080 of mouse Astrotactin-1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7234798)

Blocking Peptide: (ABIN7234798)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Antigendetails

Target: Astrotactin 1 (ASTN1)

Andere Bezeichnung: ASTN1

Hintergrund:

Synonyms: Astrotactin-1

Description: Astrotactin 1 (ASTN-1) is an integral membrane perforin-like protein known to play a critical role in neurodevelopment. The protein is responsible for the formation of neuron-glial fiber contacts in the cerebellum where it plays an important role in neuronal migration1,2.Astrotactin 1 is also expressed in post-mitotic neuronal precursors of the cerebellum, hippocampus, cerebrum and olfactory bulb. The protein demonstrates an active role in the establishment of laminar structures1.Astrotactin 1 structure reveals a large extracellular C-terminal domain that is complemented by an N-terminal cytosolic domain separated by two transmembrane α-helices1.Studies have found that genetic variations associated with Astrotactin 1 are connected to various neurodevelopmental disorders and other neurological pathologies including Alzheimer's disease1. In addition, ASTN1 null mice exhibit slow migration rates of cerebellar granule cells, smaller cerebellar size and reduced glial neuron binding2 and poorer balance and coordination than wild-type1. Conversely, increased levels of Astrotactin 1 are detected in rat brain following hippocampal injury, linking the protein to repair processes.

Gen-ID: 11899

NCBI Accession: NM_004319

UniProt: Q61137