AVPR1B Antikörper (C-Term, Intracellular)

Produktnummer ABIN7887189

Der Kaninchen Polyklonal anti-AVPR1B Antikörper (ABIN7887189) detektiert spezifisch AVPR1B in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte.

Kurzübersicht für AVPR1B Antikörper (C-Term, Intracellular) (ABIN7887189)

Target: AVPR1B (Arginine Vasopressin Receptor 1B (AVPR1B))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AVPR1B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-AVPR1B Antikörper

Bindungsspezifität: AA 399-412, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Vasopressin V1B Receptor

Kreuzreaktivität: Maus, Ratte

Kreuzreaktivität (Details): Not recommended for human samples.

Homologie: Mouse - 12,14 amino acid residues identical, human - not recommended for use with human sample

Produktmerkmale: Anti-Vasopressin V1B Receptor (AVPR1B) Antibody is directed against an epitope of rat Arginine vasopressin receptor 1B. Anti-Vasopressin V1B Receptor (AVPR1B) Antibody (ABIN7042947, ABIN7045337 and ABIN7045338) can be used in western blot analysis. It has been designed to recognize V1bR from rat and mouse samples. The antibody is not recommended for human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RAKPRPAGSLKDLE, corresponding to amino acid residues 399-412 of rat AVPR1B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7234790)

Blocking Peptide: (ABIN7234790)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu AVPR1B

Target: AVPR1B (Arginine Vasopressin Receptor 1B (AVPR1B))

Andere Bezeichnung: AVPR1B

Hintergrund:

Synonyms: V1bR, AVPR V1b, AVPR V3, Antidiuretic hormone receptor 1b, Arginine vasopressin receptor 1B, Vasopressin V3 receptor

Description: Vasopressin V1b receptor (also called V3R) is a G protein-coupled receptor (GPCR) of the Gq type, thus activating the phospholipase C signaling pathway upon activation. It is part of a family of GPCRs triggered by vasopressin that further include V1R, V2R, oxytocin receptors and purinergic receptors. While V1R and V3R are Gq GPCRs, V2R is coupled to the Gs protein and activates adenylate cyclase1,2.The V1b receptor has an intracellular C-terminal, seven transmembrane domains, and an extracellular N-tail, the transmembrane and extracellular domains are responsible for interacting with agonists and to signal for activation of the coupled Gq receptor1,2.The V1b receptor is mainly detected in the corticotrophs of the anterior pituitary gland in the brain where it regulates the release of adrenocorticotrophic hormone (ACTH) upon stimulation of vasopressin-corticotrophin-releasing hormone conjugates2.V1b KO mice show that the receptor is critical for the functionality of the hypothalamic-pituitary-adrenal axis, and demonstrate its importance in regulating glucose levels. Recent studies have also suggested that lactating rats treated with V1b antagonists, were less nurturing and similarly aggressive compared with untreated rats and that mice with reduced expression of V1b and V1a receptors have shown resistance to jet-lag1,3,4.

Gen-ID: 100909648

NCBI Accession: NM_000707

UniProt: P48974

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones