AQP3 Antikörper (C-Term, Intracellular)

Produktnummer ABIN7887070

Der Kaninchen Polyklonal anti-AQP3 Antikörper wird verwendet zum Nachweis von AQP3 in Proben von Ratte. Er wurde validiert für WB, IHC, IF, FACS und IP.

Kurzübersicht für AQP3 Antikörper (C-Term, Intracellular) (ABIN7887070)

Target: AQP3 (Aquaporin 3 (Gill Blood Group) (AQP3))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AQP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunoprecipitation (IP)

Güteklasse: KO Validated

Produktdetails anti-AQP3 Antikörper

Bindungsspezifität: AA 275-292, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Aquaporin 3 Channel

Kreuzreaktivität: Human, Maus, Ratte

Homologie: 18 amino acid residues identical, sheep,human - 15,Mouse - 17

Produktmerkmale: Anti-Aquaporin 3 Antibody (ABIN7042937, ABIN7045198 and ABIN7045199) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunoprecipitation, indirect flow cytometry, and immunohistochemistry applications. It has been designed to recognize the AQP3 channel from rat, human, and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)STEAENVKLAHMKHKEQI, corresponding to amino acid residues 275-292 of rat AQP3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Cited Application: IHC|IFC

Negative Control: (ABIN7234763)

Blocking Peptide: (ABIN7234763)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu AQP3

Target: AQP3 (Aquaporin 3 (Gill Blood Group) (AQP3))

Andere Bezeichnung: AQP3

Hintergrund:

Synonyms: AQP3, Aquaglyceroporin-3, GIL, GLIP

Description: Aquaporin 3 (AQP-3) belongs to a family of membrane proteins that allow the passage of water and certain other solutes through biological membranes. The family is composed of 13 members (AQP-0 to AQP-12).The aquaporins can be divided into two functional groups based on their permability characteristics: the aquaporins that are only permeated by water and the aquaglyceroporins that are permeated by water and other small solutes such as glycerol. This last group includes AQP-3 as well as AQP-7, AQP-9 and AQP-10.1 Little is known about the function of the two newest members, AQP-11 and AQP-12. The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores.1AQP-3 is widely expressed in several organs with prominent expression found in the skin, colon, lung and kidney. Consistent with a central function of AQP-3 in skin, mice deficient in AQP-3 have reduced skin water content and elasticity compared with wild-type mice, as well as impaired wound healing and epidermal biosynthesis.2 Furthermore, AQP-3 deficient mice were found to be resistant to skin tumor development suggesting a role for this aquaporin in tumorigenesis.3

Gen-ID: 65133

NCBI Accession: NM_004925

UniProt: P47862