Adhesion G-Protein Coupled Receptor G6 (ADGRG6) (AA 753-767), (Extracellular) Antikörper

Produktnummer ABIN7042895

Der Kaninchen Polyklonal anti-Adhesion G-Protein Coupled Receptor G6 Antikörper wird verwendet zum Nachweis von Adhesion G-Protein Coupled Receptor G6 in Proben von Maus. Er wurde validiert für WB.

Kurzübersicht für Adhesion G-Protein Coupled Receptor G6 (ADGRG6) (AA 753-767), (Extracellular) Antikörper (ABIN7042895)

Target: Adhesion G-Protein Coupled Receptor G6 (ADGRG6)

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails

Bindungsspezifität: AA 753-767, Extracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to GPR126

Spezifität: Extracellular, N-terminus

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rat,human - identical

Produktmerkmale: Anti-GPR126/ADGRG6 (extracellular) Antibody (ABIN7042895, ABIN7044451 and ABIN7044452) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. It has been designed to recognize ADGR6 from human, rat, and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)KDPVQIKIKHTRTQE, corresponding to amino acid residues 753 - 767 of mouse GPR126

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Kommentare:

Negative Control: (ABIN7234653)

Blocking Peptide: (ABIN7234653)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Antigendetails

Target: Adhesion G-Protein Coupled Receptor G6 (ADGRG6)

Andere Bezeichnung: ADGRG6

Hintergrund: Adhesion G-Protein Coupled Receptor G6, G-Protein Coupled Receptor 126, Developmentally Regulated G-Protein-Coupled Receptor, DREG, Vascular Inducible G Protein-Coupled Receptor, VIGR,GPR126 is an adhesion G-protein coupled receptor, the second largest subgroup of GPCRs1. The defining characteristic of the adhesion GPCR family is their extraordinarily large N-terminal extracellular domain important to communicate with extracellular ligands and mediate adhesive functions2.GPR126 is implicated in an increasing number of developmental defects: skeletal defects, including shortened height, adolescent idiopathic scoliosis, arthrogryposis multiplex congenital, and periodontitis. Other studies reveal that GPR126 is essential for myelination of axons in the peripheral nervous system and the heart2.Known ligands of GPCR126 are type IV collagen (COLIV) in peripheral nerves and inner ear development, Laminin-211 during Schwann cell development, and prion protein in myelination3, suggesting that GPR126 could use different signaling pathways in different tissues4.

Alternative names: Adhesion G-Protein Coupled Receptor G6, G-Protein Coupled Receptor 126, Developmentally Regulated G-Protein-Coupled Receptor, DREG, Vascular Inducible G Protein-Coupled Receptor, VIGR

Gen-ID: 57211

NCBI Accession: NM_001032394

UniProt: Q86SQ4