KEAP1 Antikörper (AA 65-160) (FITC)
Kurzübersicht für KEAP1 Antikörper (AA 65-160) (FITC) (ABIN702092)
Target
Alle KEAP1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
 - AA 65-160
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Kreuzreaktivität
 - Human, Maus, Schwein, Kaninchen, Ratte
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Homologie
 - Dog,Cow
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Aufreinigung
 - Purified by Protein A.
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Immunogen
 - KLH conjugated synthetic peptide derived from human KEAP1
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Isotyp
 - IgG
 
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Applikationshinweise
 - 
                        IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 
                                            
Beschränkungen
 - Nur für Forschungszwecke einsetzbar
 
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Format
 - Liquid
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Konzentration
 - 1 μg/μL
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Buffer
 - Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
 - ProClin
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Vorsichtsmaßnahmen
 - This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Lagerung
 - -20 °C
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Informationen zur Lagerung
 - Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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Haltbarkeit
 - 12 months
 
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- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
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Andere Bezeichnung
 - KEAP1
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Hintergrund
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Synonyms: INrf2, KLHL19, Kelch-like ECH-associated protein 1, Cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, KIAA0132
Background: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
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Gen-ID
 - 9817
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UniProt
 - Q14145
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Pathways
 - Maintenance of Protein Location
 
Target
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