TLN1 Antikörper (AA 1601-1750)

Produktnummer ABIN701695

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TLN1 in ELISA, IHC (p), IHC (fro), IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Maus und Ratte und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für TLN1 Antikörper (AA 1601-1750) (ABIN701695)

Target: TLN1 (Talin 1 (TLN1))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLN1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-TLN1 Antikörper

Bindungsspezifität: AA 1601-1750

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Talin 1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-TLN1 Antikörper (ABIN701695)

He, Meng, Yao, Jiang, Wu, Wu: "The essential role of inorganic substrate in the migration and osteoblastic differentiation of mesenchymal stem cells." in: Journal of the mechanical behavior of biomedical materials, Vol. 59, pp. 353-65, (2016) (PubMed).

Dingyu, Fanjie, Zhengzheng, Baosheng, Chao, Yi, Huiwen, Jun, Gang: "Regulation of Intracellular Structural Tension by Talin in the Axon Growth and Regeneration." in: Molecular neurobiology, (2015) (PubMed).

Details zu TLN1

Target: TLN1 (Talin 1 (TLN1))

Andere Bezeichnung: Talin1

Hintergrund:

Synonyms: TLN 1, ILWEQ, Talin 1, Talin, TLN, TLN1, TLN 2, Talin 2, Talin 2, TLN2.

Background: Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-270 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations.

Gen-ID: 7094, 83660

UniProt: Q9Y4G6, Q9Y490

Pathways: Cell-Cell Junction Organization, ER-Nucleus Signaling, Maintenance of Protein Location