CD8 alpha Antikörper

Produktnummer ABIN7013939

Dieses Anti-CD8 alpha-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CD8 alpha in FACS, WB, IP, IHC (fro), IHC (p) und Func. Geeignet für Ratte.

Kurzübersicht für CD8 alpha Antikörper (ABIN7013939)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD8 alpha Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func)

Klon: OX-8

Produktdetails anti-CD8 alpha Antikörper

Verwendungszweck: Anti-Rt CD8a Purified Low Endotoxin

Spezifität: The mouse monoclonal antibody OX-8 recognizes the hinge-like membrane-proximal extracellular domain of rat CD8a (32-34 kDa, alpha chain of the CD8 antigen).

Aufreinigung: Purified by protein-A affinity chromatography.

Endotoxin-Niveau: Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Immunogen: High Mw glycoproteins from rat thymocytes

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 1-4 μg/mL.
Functional application: Blocking

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Details zu CD8 alpha

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Andere Bezeichnung: CD8a

Hintergrund: CD8a molecule,The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.,Ly-2, Ly-B, Ly-35, Lyt-2

Gen-ID: 24930

UniProt: P07725

Pathways: T-Zell Rezeptor Signalweg