Der Kaninchen Polyklonal anti-IMPDH2 Antikörper (ABIN7010582) detektiert spezifisch IMPDH2 in IF.
Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.