ADAM10 Antikörper (AA 501-600)

Produktnummer ABIN701020

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ADAM10 in WB, ELISA, IF (cc), IF (p), IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für ADAM10 Antikörper (AA 501-600) (ABIN701020)

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAM10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-ADAM10 Antikörper

Bindungsspezifität: AA 501-600

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ADAM10

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-ADAM10 Antikörper (ABIN701020)

Ku, Li, Gao, Zhang, Yan, Ji, Li, Sang: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." in: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).

Angenendt, Reuter, Kentrup, Benk, Neumann, Hüve, Martens, Schwöppe, Kessler, Schmidt, Sauer, Brand, Mikesch, Lenz, Mesters, Müller-Tidow, Hartmann, Wardelmann, Neri, Berdel, Roesli, Schliemann: "An atlas of bloodstream-accessible bone marrow proteins for site-directed therapy of acute myeloid leukemia." in: Leukemia, Vol. 32, Issue 2, pp. 510-519, (2017) (PubMed).

Li, Xie, He, Wang, Duan, Yang, Wang: "Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis." in: Gene, Vol. 562, Issue 1, pp. 117-27, (2015) (PubMed).

Details zu ADAM10

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Andere Bezeichnung: ADAM10

Hintergrund:

Synonyms: RAK, kuz, AD10, AD18, MADM, CD156c, HsT18717, Disintegrin and metalloproteinase domain-containing protein 10, ADAM 10, CDw156, Kuzbanian protein homolog, Mammalian disintegrin-metalloprotease, ADAM10

Background: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

Gen-ID: 102

UniProt: O14672

Pathways: Notch Signalweg, EGFR Signaling Pathway