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RAG2 Antikörper

Dieses Anti-RAG2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RAG2 in WB. Geeignet für Maus.
Produktnummer ABIN7256152

Kurzübersicht für RAG2 Antikörper (ABIN7256152)

Target

Alle RAG2 Antikörper anzeigen
RAG2 (Recombination Activating Gene 2 (RAG2))

Reaktivität

  • 48
  • 14
  • 13
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Maus

Wirt

  • 40
  • 8
Kaninchen

Klonalität

  • 42
  • 6
Polyklonal

Konjugat

  • 24
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser RAG2 Antikörper ist unkonjugiert

Applikation

  • 21
  • 14
  • 13
  • 13
  • 7
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Produktmerkmale

    Polyclonal Antibody

    Aufreinigung

    Affinity purification

    Immunogen

    Recombinant fusion protein of human RAG2 (NP_001230715.1).

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    RAG2 (Recombination Activating Gene 2 (RAG2))

    Andere Bezeichnung

    RAG2

    Hintergrund

    This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

    Molekulargewicht

    Observed_MW: 59 kDa

    Calculated_MW: 59 kDa

    Gen-ID

    5897

    UniProt

    P55895

    Pathways

    Chromatin Binding, Production of Molecular Mediator of Immune Response
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