ERH Antikörper

Produktnummer ABIN7253677

Dieses Anti-ERH-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ERH in ELISA und IHC. Geeignet für Human und Maus.

Kurzübersicht für ERH Antikörper (ABIN7253677)

Target: ERH (Enhancer of Rudimentary Homolog (ERH))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERH Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-ERH Antikörper

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Fusion protein of human ERH

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:40-1:200, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.96 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ERH

Target: ERH (Enhancer of Rudimentary Homolog (ERH))

Andere Bezeichnung: ERH

Hintergrund: ERH (enhancer of rudimentary homolog), also known as DROER, is a 104 amino acid transcriptional coregulator that is ubiquitously expressed and highly conserved among eukaryotes. ERH may play a role in cell cycle regulation and pyrimidine biosynthesis. ERH represses the function of the coactivator PCBD, preventing it from enhancing the activity of the tissue-specific transcription factor HNF-1 (hepatocyte nuclear factor-1). HNF-1 is a homeodomain transcription factor that binds DNA as a dimer and the HNF-1/DNA complex is stabilized by PCBD. By repressing PCBD, ERH disrupts the stability of the HNF-1/DNA complex, affecting the expression of multiple genes in the liver. The structure of ERH is characterized by a single domain consisting of three alpha-helices and four beta-strands. ERH has a long flexible loop that is significantly conserved, suggesting that this loop region may be important for the function of ERH. ERH has two casein kinase II phosphorylation sites that are thought to disrupt the ability of ERH to dimerize.

UniProt: P84090